摘要
目的 探讨去甲肾上腺素单独或联合特利加压素在脓毒症休克治疗中的效果。方法 以随机数字表法将2018年8月至2021年6月桂林市人民医院重症医学科收治的80例脓毒症休克患者予以分组,对照组40例,采用去甲肾上腺素治疗;观察组40例,采用去甲肾上腺素联合特利加压素治疗,记录两组患者维持治疗前、输注12、24和36 h时去甲肾上腺素剂量,观察两组维持治疗前、输注12、24和36 h时微循环及肠道功能变化。结果 观察组维持治疗前、输注12、24和36 h时去甲肾上腺素剂量分别与同时点对照组对比,明显较低(P<0.05);观察组输注12、24、36 h时氧输送(DO_(2)),氧耗(VO_(2)),中心静脉氧饱和度(SvO_(2))与同时点对照组对比,明显较高(P<0.05);观察组输注12、24、36 h时D-乳酸(D-Lac)、二胺氧化酶(DAO)、肠型脂肪酸结合蛋白(I-FABP)与同时点对照组对比,明显较低(P<0.05)。结论 去甲肾上腺素联合特利加压素治疗脓毒症休克,可减少去甲肾上腺素用药剂量,有效促进微循环及肠道功能恢复,效果优于NE单独治疗。
Objective To explore the effect of Norepinephrine(NE)alone or combined with Terlipressin(TP)in the treatment of septic shock.Methods A total of 80 patients with septic shock in Department of Intensive Care Unit,Guilin People’s Hospital from August 2018 to June 2021 were divided into groups by random number table method.Forty cases in the control group were treated with NE,and 40 cases in the observation group were treated with NE+TP.The NE doses and of the two groups before maintenance treatment,and 12 h,24 h and 36 h after infusion were recorded respectively.The changes of microcirculation and intestinal function of the two groups before maintenance treatment,and 12 h,24 h and 36 h after infusion were observed respectively.Results The NE dose of the observation group before maintenance therapy,12 h,24 h,and36 h after infusionn were significantly lower compared with the control group(P<0.05).The oxygen delivery(DO_(2)),oxygen consumption(VO_(2))and mixed venous oxygen saturation(SvO_(2))in the observation group at 12 h,24 h,and 36 h after infusion were significantly higher compared with the control group(P<0.05).The D-lactic acid(D-Lac),diamine oxidase(DAO),and intestinal fatty acid binding protein(I-FABP)in the observation group 12 h,24 h,and 36 h after infusion were significantly lower compared with the control group(P<0.05).Conclusion NE combined with TP in the treatment of septic shock can reduce the dose of NE medication,effectively promote microcirculation and intestinal function recovery.The effect is better than that of NE alone.
作者
黄巍
张庆祥
胡小文
罗丹
李小玲
HUANG Wei;ZHANG Qing-xiang;HU Xiao-wen;LUO Dan;LI Xiao-ling(Department of Intensive Care Unit,Guilin People's Hospital,Guangxi Gulin 541002,China)
出处
《临床药物治疗杂志》
2022年第4期22-25,共4页
Clinical Medication Journal
基金
桂林市科学与技术开发计划项目(桂林市科学技术局)。
