摘要
目的:探讨ABCB1基因多态性对乳腺癌化疗所致血液学毒性的影响观察。方法:选择92例乳腺癌患者作为研究对象并检测ABCB1基因分型,分析不同基因多态性患者的血液学毒性结果。结果:92例乳腺癌患者中,G2677T/A点位GG占15.22%、GT/A占57.60%、TT/AA/AT占27.18%;C3435T点位CC占23.91%、CT占54.35%、TT占21.74%;G2677T/A、C3435T基因型分布符合遗传平衡定律(P>0.05)。G2677T/A各基因型血液学毒性发生情况无差异(P>0.05);C3435T各基因型血液学毒性发生情况比较有差异(P<0.05)。G2677T/A各基因型和C3435T各基因型近期疗效比较无差异(P>0.05)。结论:检测ABCB1基因C3435T点位基因多态性对乳腺癌患者化疗具有重要的参考价值。
Objective:To investigate the effect of ABCB1 gene polymorphism on hematological toxicity caused by chemotherapy in breast cancer.Methods:Ninety-two breast cancer patients were selected as the research subjects and ABCB1 genotype was detected,and the hematological toxicity results of patients with different gene polymorphisms were analyzed.Results:Among the 92 breast cancer patients,GG accounted for 15.22%,GT/A accounted for 57.60%,TT/AA/AT accounted for 27.18%in G2677T/A site;CC accounted for 23.91%,CT accounted for 54.35%,and TT accounted for 21.74%in G3435T site;G2677T/A,C3435T genotype distribution conformed to the law of genetic equilibrium(P>0.05).There was no difference in the occurrence of hematological toxicity among G2677T/A genotypes(P>0.05).There were differences in the occurrence of hematological toxicity among C3435T genotypes(P>0.05).There was no difference in the short-term curative effect between the G2677T/A genotypes and the C3435T genotypes(P>0.05).Conclusion:Detection of ABCB1 gene C3435T locus polymorphism has important reference value for chemotherapy in breast cancer patients.
作者
李倩
王西勇
Li Qian;Wang Xiyong(Suzhou Hospital Affiliated to Anhui Medical University,Suzhou Anhui 234000)
出处
《现代科学仪器》
2022年第2期134-138,共5页
Modern Scientific Instruments
基金
安徽省高等学校自然科学研究项目(编号:KJ2020A1145)
宿州市科技攻关计划项目(编号:202019)。
关键词
ABCB1
单核苷酸多态性
紫杉醇
化疗
血液学毒性
ABCB1
single nucleotide polymorphism
paclitaxel
chemotherapy
hematological toxicity
