摘要
目的:探讨病毒性脑炎和细菌性脑炎患儿血清学指标和脑脊液指标的变化,为病毒性脑炎的临床诊治提供借鉴依据。方法:选取寿光市人民医院于2019年12月-2020年12月收治的病毒性脑炎患儿88例作为病毒组、细菌性脑炎患儿88例作为细菌组和非中枢神经系统感染的头疼患儿88例作为对照组。观察和比较三组血清与脑脊液的C反应蛋白(CRP)、胱抑素C(Cys C)、血清S100B蛋白(S100B)、基质金属蛋白酶-9(MMP-9)、免疫球蛋白(IgG)和脑脊液中白细胞数量、葡萄糖、蛋白、氯化物含量。结果:三组血清与脑脊液的CRP、S100B、MMP-9、IgG和Cys C比较,差异均有统计学意义(P<0.05)。细菌组血清与脑脊液CRP、MMP-9、IgG均高于病毒组和对照组,病毒组均高于对照组(P<0.05);病毒组和细菌组血清S100B均高于对照组(P<0.05),而病毒组和细菌组血清S100B比较,差异无统计学意义(P>0.05);病毒组血清Cys C高于细菌组和对照组,且细菌组高于对照组(P<0.05);细菌组脑脊液IgG高于病毒组和对照组(P<0.05),病毒组与对照组比较,差异无统计学意义(P>0.05);病毒组脑脊液Cys C低于细菌组和对照组,且细菌组低于对照组(P<0.05)。三组脑脊液白细胞数量、葡萄糖、蛋白和氯化物含量比较,差异均有统计学意义(P<0.05);细菌组的白细胞数量高于病毒组和对照组,且病毒组高于对照组(P<0.05);细菌组的蛋白均高于病毒组和对照组,而葡萄糖、氯化物均低于病毒组和对照组(P<0.05),病毒组葡萄糖高于对照组(P<0.05),而病毒组和对照组的蛋白与氯化物比较,差异无统计学意义(P>0.05)。结论:病毒性脑炎和细菌性脑炎患儿的血清学指标和脑脊液指标会出现不同程度的特异性改变,在临床实践过程中要结合患儿的症状进行病情的判断和临床诊治,对于上述指标的监测有助于病毒性脑炎和细菌性脑炎的鉴别诊断,同时对于临床治疗也具有重要的指导意义�
Objective:To investigate the changes of serological indexes and cerebrospinal fluid indexes in children with viral encephalitis and bacterial encephalitis,and to provide reference for clinical diagnosis and treatment of viral encephalitis.Method:A total of 88 children with viral encephalitis admitted to Shouguang People’s Hospital from December 2019 to December 2020 were selected as the viral group,88 children with bacterial encephalitis as the bacterial group,and 88 children with headache without central nervous system infection as the control group.The C reactive protein(CRP),cystatin C(Cys C),S100B protein(S100B),matrix metalloproteinase-9(MMP-9),immunoglobulin(IgG)in serum and cerebrospinal fluid and white blood cell number,glucose,protein,chloride content in cerebrospinal fluid of three groups were observed and compared.Result:There were statistically significant differences in CRP,S100B,MMP-9,IgG and Cys C in serum and cerebrospinal fluid of the three groups(P<0.05).CRP,MMP-9 and IgG in serum and cerebrospinal fluid of bacterial group were higher than those of virus group and control group,while those of virus group were higher than those of control group(P<0.05).Serum S100B in virus group and bacteria group were higher than that in control group(P<0.05),but there was no statistical significance in serum S100B between virus group and bacteria group(P>0.05).The serum Cys C of virus group was higher than that of bacterial group and control group,and bacterial group was higher than control group(P<0.05).The IgG in bacterial group was higher than that in virus group and control group(P<0.05),but there was no significant difference between virus group and control group(P>0.05).The cerebrospinal fluid Cys C of virus group was lower than that of bacterial group and control group,and that of bacterial group was lower than control group(P<0.05).There were statistically significant differences in the number of white blood cells,glucose,protein and chloride contents in cerebrospinal fluid among the three groups(P<0.
作者
徐金辉
杨艳萍
XU Jinhui;YANG Yanping(Shouguang People’s Hospital,Shandong Province,Shouguang 262700,China;不详)
出处
《中国医学创新》
CAS
2022年第13期20-24,共5页
Medical Innovation of China
关键词
病毒性脑炎
细菌性脑炎
血清学指标
脑脊液
Viral Encephalitis
Bacterial encephalitis
Serological indexes
Cerebrospinal fluid
