摘要
宫颈癌是女性死亡的主要原因之一,溶瘤病毒是具有复制能力的病毒,它能够选择性杀死肿瘤细胞而对正常组织和细胞无损伤作用。病毒特异性感染肿瘤细胞后使肿瘤细胞溶解,被溶解的肿瘤细胞触发机体内获得性免疫反应和适应性免疫反应。本综述介绍了几种典型溶瘤病毒对宫颈癌的影响,包括单纯疱疹病毒、腺病毒、新城疫病毒和辛德毕斯病毒,除此以外本综述还涉及这几种溶瘤病毒的基因组特征、基因编辑方式、对机体的作用机制及发展前景的相关介绍。总之,溶瘤病毒在宫颈癌的治疗方面具有潜力,但目前这方面的探索仅停留在基础实验层面,虽然现阶段溶瘤病毒的临床试验正在开展阶段,但更多基础研究成果的转化需要更多地探索,以便于溶瘤病毒能够更好地为癌症的治疗服务。
Cervical cancer is one of the main causes of death in women.Oncolytic virus is a virus with replication ability.It can selectively kill tumor cells without damaging normal tissues and cells.After the virus specifically infects tumor cells,the tumor cells are lysed,and the lysed tumor cells trigger the adaptive immune response and adaptive immune response in the body.This article introduces the effects of several typical oncolytic virus on cervical cancer,including herpes simplex virus,adenovirus,Newcastle disease virus and Sindbis virus.In addition,this article also covers the genome characteristics,gene editing methods,mechanism of action on the body and the development prospects of these oncolytic viruses.In general,oncolytic viruses have potential in the treatment of cervical cancer,but the current exploration in this area only stays at the basic experimental level.Although clinical trials of oncolytic viruses are currently underway,there are more basic research results.Transformation requires more exploration so that oncolytic viruses can better serve the treatment of cancer.
作者
周影
耿志欣
孙建
戚小艳
裴兵
ZHOU Ying;GENG Zhixin;SUN Jian;QI Xiaoyan;PEI Bing(Department of Clinical Laboratory,the Affiliated Suqian First People’s Hospital of Nanjing Medical University,Suqian,Jiangsu 223800,China)
基金
江苏省妇幼科研项目(编号:F201868)。
关键词
溶瘤病毒
宫颈癌
单纯疱疹病毒
腺病毒
抗肿瘤作用
Cervical cancer
Oncolytic virus
Herpes simplex virus
Adenovirus
Anti-tumor effect
