摘要
细胞死亡抑制药物的研究对于疾病的预防和治疗具有重要意义。正常的细胞死亡在维持机体正常的生理生态方面具有重要作用,细胞的被动死亡则会引发机体的炎症反应和机体功能障碍等一系列疾病。细胞死亡抑制药物可以针对相应的细胞死亡过程通过不同的机制进行调控,从而延缓细胞死亡进程或者抑制与疾病相关细胞的死亡,发挥一定的治疗作用。论文通过对细胞死亡方式的介绍,阐明细胞死亡抑制药物的种类及作用机制,对抑制细胞死亡药物在治疗神经退行性疾病、糖尿病等慢性疾病中的应用及研究进展进行综述,以期为细胞死亡抑制药物的研发及临床应用提供有价值的参考。
The study of cell death inhibitor drugs has great significance for the prevention and treatment of diseases.Normal cell death plays an important role in maintaining the normal physiology and ecology of the body,while passive cell death will trigger a series of diseases such as inflammatory response and body dysfunction.Cell death inhibitor drugs can regulate the corresponding cell death process through different mechanisms,so as to delay the process of cell death or inhibit the death of disease-related cells,and play a therapeutic role.Through the introducing the modes of cell death,the paper clarified the types and mechanism of cell death inhibitor drugs,and summarized the application and research progress of inhibitor drugs in the treatment of neurodegenerative diseases,diabetes and other chronic diseases,with a view to developing and studying the clinic value of cell death inhibitor drugs,for providing a valuable reference.
作者
孙东杰
雷连成
张付贤
SUN Dong-jie;LEI Lian-cheng;ZHANG Fu-xian(College of Animal Science,Yangtze University,Jingzhou,Hubei,434000,China;College of Veterinary Medicine,Jilin University,Changchun,Jilin,130062,China)
出处
《动物医学进展》
北大核心
2022年第5期117-121,共5页
Progress In Veterinary Medicine
基金
国家自然科学基金国际(地区)合作与交流项目(31520103917)。
关键词
细胞死亡
抑制细胞死亡药物
机制
应用
cell death
cell death inhibitor drug
mechanism
application
