摘要
目的:观察比较银屑病患者肠道屏障功能相关指标的变化情况,分析其临床意义。方法:2016年7月至2018年4月期间,收集中山大学孙逸仙纪念医院皮肤科病房收治的50名银屑病患者以及39名健康志愿者的血清标本进行肠道屏障功能指标检测,并收集住院病人的临床及检验资料进行相关性分析。结果:与正常人相比,银屑病患者细菌毒素水平、D-乳酸水平升高。两组研究对象的二胺氧化酶水平无统计学差异。银屑病患者血液中的D-乳酸与α-L-岩藻糖苷酶相关,相关系数为0.33,细菌毒素水平与中肌酐的水平相关,相关系数为0.31。未发现银屑病患者的肠道屏障指标与其病程、住院次数、银屑病严重程度、疾病亚型、是否使用过免疫抑制剂、是否合并心脑血管疾病等指标以及其他生化指标相关。结论:银屑病患者血液中细菌毒素、D-乳酸高于正常人,提示肠道屏障功能受损。
Objective:To compare intestinal barrier function changes in patients with psoriasis and analyze its clinical significance. Methods:From July 2016 to April 2018,the serum samples of 50 psoriatic patients from the dermatology ward of Sun Yat-sen Memorial Hospital of Sun Yat-sen University and 39 healthy volunteers were collected.The clinical and laboratory data of inpatients were collected for analysis. Results:Compared with normal subjects,the levels of bacterial toxin and D-lactic acid in patients with psoriasis were higher. There was no significant difference in the level of diamine oxidase between the two groups. The level of D-lactic acid in the blood of patients with psoriasis was correlated with α-L-fucosidase,with a correlation coefficient of 0.33,and the level of bacterial toxin correlated with the level of creatinine,with a correlation coefficient of 0.33. We did not find that the intestinal barrier index of patients with psoriasis was related to the duration of disease,the times of hospitalizations,the severity of psoriasis,disease subtypes,the use of immunosuppressants,cardio-cerebrovascular diseases and other biochemical indexes. Conclusion:The levels of bacterial toxin and D-lactic acid in blood of patients with psoriasis are higher than those of normal subjects,suggesting that the intestinal barrier function is impaired.
作者
黄丹琪
熊慧
郭庆
唐增奇
HUANG Dan-qi;XIONG Hui;GUO Qing;TANG Zeng-qi(Department of Dermatology,Sun Yat-sen Memorial Hospital,Sun Yat-sen University,Guangdong,510120)
出处
《岭南急诊医学杂志》
2022年第2期137-139,共3页
Lingnan Journal of Emergency Medicine
关键词
银屑病
肠道屏障
细菌毒素
D-乳酸
psoriasis
intestinal barrier
bacterial toxin
D-lactic acid
