摘要
肿瘤微环境中肿瘤细胞与神经细胞之间相互浸润,最终促进肿瘤的发生发展。众多证据表明,神经新生对肿瘤微环境起到关键的调控作用。该文通过回顾神经新生与肿瘤及肿瘤微环境之间的相互作用,梳理了包括神经生长因子等影响神经新生介导肿瘤增殖、转移的因素,及通过调控神经信号对肿瘤的检测及治疗意义。旨在从神经新生角度辅助临床解决肿瘤增殖与转移等问题。
In the tumor microenvironment,tumor cells and nerve cells infiltrate each other,ultimately promoting the occurrence and development of tumor.Numerous evidence shows that neurogenesis plays a key role in the regulation of tumor microenvironment.By reviewing the interaction between neurogenesis and tumor and tumor microenvironment,this paper summarizes the factors including nerve growth factor that affects neurogenesis mediated tumor proliferation and metastasis,and the significance of tumor detection and treatment by regulating nerve signal.The purpose of this study is to assist clinical treatment of tumor proliferation and metastasis from the perspective of neurogenesis.
作者
宋梦瑶
宋莉
周银银
贾琦
李晓曼
陆茵
SONG Meng-yao;SONG Li;ZHOU Yin-yin;JIA Qi;LI Xiao-man;LU Yin(Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica,School of Pharmacy,Nanjing 210023,China;Jiangsu Collaborative Innovation Center of Traditional Chinese Medicine Prevention and Treatment of Tumor,Nanjing University of Chinese Medicine,Nanjing 210023,China;Jiangsu International Cooperative Joint Laboratory of Traditional Chinese Medicine and Regenerative Medicine,Nanjing 210023,China)
出处
《中国药理学通报》
CAS
CSCD
北大核心
2022年第5期665-668,共4页
Chinese Pharmacological Bulletin
基金
江苏省中医药领军人才项目(No SLJ0229)。
关键词
神经新生
轴突新生
肿瘤增殖、转移
肿瘤微环境
NGF
靶向治疗
neurogenesis
axonogenesis
tumor proliferation and metastasis
tumor microenvironment
nerve growth factor
targeted therapy
