摘要
血瘀理论源自《黄帝内经》,通常是指因气虚、气滞、寒凝、血热及外伤等病因病机导致的血行不畅、血液运行缓慢或停滞。现代研究认为血瘀证是引起代谢性疾病的原因之一,参与了心脑血管疾病、糖尿病、肾病、高血压病、高脂血症等多种疾病的发生和发展过程。因此,血瘀证模型建立方法的稳定对该领域的研究十分重要。目前,主要从发病诱因、病理改变及病证结合3个角度建立血瘀证动物模型,但模型的建立方法、评价标准和方法尚有很多问题。文章综述了血瘀证动物模型建模方法及评价标准,以期为血瘀证相关疾病的研究以及活血化瘀中药的筛选提供科学依据。
The theory of blood stasis originated from the Huangdi Neijing, which usually refers to the poor blood flow, slow or stagnant blood flow caused by qi deficiency, qi stagnation, cold coagulation, blood heat and trauma. Modern research believes that blood stasis syndrome is one of the causes of metabolic diseases, which is involved in the occurrence and development cardiovascular and cerebrovascular diseases, diabetes, nephropathy and hyperlipidemia and other diseases. Therefore,scientific and reasonable blood stasis syndrome model is very important for the research in this field. According to the literature,there are three methods to establish the blood stasis syndrome model. Which are based on the pathogenesis, pathological changes and the combination of disease and syndrome. However, there are still many problems in the establishment of model, evaluation criteria and methods, which need further study. Therefore, this paper reviews the modeling methods and evaluation criteria of animal models of blood stasis syndrome, in order to provide scientific basis for the research of blood stasis related diseases and traditional Chinese medicine for promoting blood circulation and removing blood stasis.
作者
廖利
赵兴桃
王成
邓英
周梦婷
李芸霞
任波
LIAO Li;ZHAO Xing-tao;WANG Cheng;DENG Ying;ZHOU Meng-ting;LI Yun-xia;REN Bo(State Key Laboratory of Characteristic Chinese Medicine Resources in Southwest China,School of Pharmacy,Chengdu University of TCM,Chengdu 611137,China)
出处
《中华中医药杂志》
CAS
CSCD
北大核心
2021年第12期7256-7260,共5页
China Journal of Traditional Chinese Medicine and Pharmacy
基金
四川省科技厅省青年科技创新研究团队专项(No.2017TD0001)
四川省科技厅应用基础研究项目(No.2018JY0186)。
关键词
血瘀证
病理机制
动物模型
评价指标
Blood stasis syndrome
Pathological mechanism
Animal model
Evaluation index
