摘要
目的:探讨枳实薤白桂枝汤在冠心病不稳定型心绞痛痰浊痹阻型患者治疗中的应用价值。方法:将2017年2月至2019年12月因冠心病不稳定型心绞痛于江西省宜春市中医院就诊且中医证型属于痰浊痹阻型的161例患者纳入研究,纳入研究前均用随机数表法对患者进行分组。对照组(80例)采用单纯西医治疗,观察组(81例)则在对照组治疗基础上联合枳实薤白桂枝汤口服治疗,治疗2周后比较两组临床疗效、部分血清炎性因子及血管内皮功能。结果:治疗后,与对照组比较,观察组血清肿瘤坏死因子-α、白介素-6、可溶性细胞间黏附分子水平、血清脂蛋白磷脂酶A2、内皮素-1水平、每周硝酸甘油用量、每次持续时间、每周发作次数均显著降低(P<0.01),一氧化氮水平显著升高(P<0.01);观察组总有效率[92.59%(75/81)]显著优于对照组[80.00%(64/80)](P<0.05);两组不良反应总发生率差异无统计学意义。结论:联合枳实薤白桂枝汤治疗冠心病不稳定型心绞痛痰浊痹阻型患者,可减轻炎症反应,调节血管内皮功能,改善心绞痛发作情况,有助于临床疗效提高。
Objective: To explore the application value of Zhishi Xiebai Guizhi Decoction in the treatment of patients with unstable angina pectoris(phlegm-turbid arthralgia type) of coronary heart disease, and to observe its inflammation index and angina pectoris, aiming to provide effective for this disease treatment method. Methods: From February 2017 to December 2019, 161 patients with unstable angina pectoris due to coronary heart disease were treated in Traditional Chinese Medicine Hospital of Yichun and the TCM syndrome type was phlegm and phlegm obstruction type. The random number table method was used before the study. Patients are grouped. A total of 80 cases in the control group were treated with Western medicine alone, and 81 cases in the observation group were treated with Zhishi Xiebai Guizhi Decoction orally based on the control group’s treatment. The clinical efficacy, some serum inflammatory factors and vascular endothelial function were compared after 2 weeks of treatment. Results: After treatment, serum tumor necrosis factor-α, interleukin-6, soluble intercellular adhesion molecules. The level was lower than the control group(P<0.01). After treatment, the serum lipoprotein phospholipase A2 and endothelin-1 level is lower than the control group, and the nitric oxide level is higher than the control group(P<0.05). The weekly nitroglycerin dosage, each duration, and weekly attacks in the observation group were lower than those of the control group(P<0.01). The total effective rate of the observation group [92.59%(75/81)] was significantly better than that of the control group [80.00%(64/80)](P<0.05). There was no significant difference in the total incidence of adverse reactions between the two groups. Conclusion: For patients with unstable angina pectoris of coronary heart disease(phlegm-turbidity obstructive type) combined with Zhishi Xiebai Guizhi Decoction is important, it can reduce inflammation, regulate vascular endothelial function, improve angina pectoris, and contribute to clinical efficacy impro
作者
袁泉英
甘翔
鲍火庚
黎梓旺
刘希茜
李林
YUAN Quan-ying;GAN Xiang;BAO Huo-geng;LI Zi-wang;LIU Xi-qian;LI Lin(Traditional Chinese Medicine Hospital of Yichun,Yichun 336000,China;Affiliated Hospital of Jiangxi University of Chinese Medicine,Nanchang 330006,China)
出处
《中华中医药杂志》
CAS
CSCD
北大核心
2021年第11期6893-6897,共5页
China Journal of Traditional Chinese Medicine and Pharmacy
基金
江西省卫生计生委中医药科研课题(No.2016A139)。
