摘要
目的分析血清胃泌素(Gas)、生长转化因子-α(TGF-α)对老年幽门螺杆菌(Hp)阳性十二指肠溃疡(DU)患者四联疗法预后的判断价值。方法前瞻性选取该院2017年4月至2020年5月接受四联疗法的200例老年Hp阳性DU患者,治疗4周后参照相关标准评估患者疗效,患者分为预后不良组与预后良好组;询问并记录患者相关基线资料,于治疗前、治疗4周检测Gas、TGF-α及相关实验室指标,重点分析治疗前血清Gas、TGF-α判断老年Hp阳性DU患者四联疗法预后不良风险的价值。结果200例老年Hp阳性DU患者治疗4周Gas水平低于治疗前,TGF-α水平高于治疗前(P<0.05)。200例老年Hp阳性DU患者采用四联疗法治疗4周,42例预后不良,占21.00%;预后不良组治疗前Gas水平高于预后良好组,TGF-α水平低于预后良好组(P<0.05);两组间其他基线资料比较,差异无统计学意义(P>0.05)。经Logistic回归分析结果显示,治疗前Gas过表达可能是老年Hp阳性DU患者四联疗法预后不良的危险因素(OR>1,P<0.05),TGF-α过表达可能是老年Hp阳性DU患者四联疗法预后不良的保护因素(OR<1,P<0.05);受试者工作特征(ROC)曲线结果显示,治疗前血清Gas、TGF-α单项及联合预测老年Hp阳性DU患者四联疗法预后不良风险的曲线下面积(AUC)均>0.800,均有一定预测价值。结论老年Hp阳性DU患者四联疗法预后不良与患者治疗前Gas过表达、TGF-α低表达有关,且血清Gas、TGF-α水平对判断老年Hp阳性DU患者四联疗法预后不良风险有一定价值。
Objective To analyze the value of serum gastrin(Gas),transforming growth factor-α(TGF-α)on prognosis of elderly patients with Helicobacter pylori(Hp)positive and duodenal ulcer(DU)treated with quadruple therapy.Methods A total of 200 elderly patients with Hp positive and DU who received quadruple therapy in the hospital from April 2017 to May 2020 were prospectively selected,the curative effect of patients was evaluated referred to the relevant standards at 4 weeks of treatment,and they were divided into a poor prognosis group and a good prognosis group.The baseline data of patients were asked and recorded,Gas,TGF-αand related laboratory indexes were detected before and at 4 weeks of treatment,and the value of serum Gas and TGF-αbefore treatment in judging the poor prognosis of elderly Hp positive and DU patients treated with quadruple therapy was mainly analyzed.Results Gas level in 200 elderly patients with Hp positive and DU at 4 weeks of treatment was lower than that before treatment,and the level of TGF-αwas higher than that before treatment(P<0.05).Among 200 elderly patients with Hp positive and DU at 4 weeks of quadruple therapy,42 patients had poor prognosis,accounting for 21.00%.The level of Gas before treatment in the poor prognosis group was higher than that in the good prognosis group,and the level of TGF-αwas lower than that in the good prognosis group(P<0.05).There were no statistical significant differences in other baseline data between the two groups(P>0.05).The results of Logistic regression analysis showed that the over expression of Gas might be a risk factor of poor prognosis of elderly patients with Hp positive and DU treated with the quadruple therapy(OR>1,P<0.05).The overexpression of TGF-αmight be a protective factor of poor prognosis of the quadruple therapy in elderly patients with Hp positive and DU treated with the quadruple therapy(OR<1,P<0.05).The receiver operating characteristics(ROC)curve results showed that area umder curve(AUC)of single and combined detection of serum Ga
作者
杨万荷
崔路佳
王昌高
昝慧
YANG Wanhe;CUI Lujia;WANG Changgao;ZAN Hui(Department of Gastroenterology,Hainan Provincial People′s Hospital/Hainan Hospital Affiliated to Hainan Medical College,Haikou,Hainan 570311,China)
出处
《国际检验医学杂志》
CAS
2022年第9期1055-1059,共5页
International Journal of Laboratory Medicine
基金
海南省科学技术研究与发展计划项目(817316)。
