摘要
目的研究阶梯式营养干预对胃癌术后化疗患者化疗耐受性、免疫因子及不良反应的影响。方法选择2018年7月至2021年6月于我院行手术治疗并行术后化疗的胃癌患者106例,依照随机数字表法分为试验组(n=53)与对照组(n=53)。两组均行CAPEOX方案化疗,对照组术后给予常规饮食干预,试验组给予常规饮食干预+阶梯式营养干预。观察两组患者化疗耐受性。两组干预前后血清前白蛋白、白蛋白、总蛋白等营养指标,血清CD3;、CD4^(+)、CD8^(+)、CD4^(+)/CD8^(+)等免疫因子水平及不良反应。结果试验组患者化疗耐受性良好率大于对照组(P<0.05)。化疗后,试验组血清前白蛋白、白蛋白、总蛋白水平均高于对照组(P<0.05)。化疗后,试验组CD3;、CD4^(+)、CD4^(+)/CD8^(+)水平均高于对照组,CD8^(+)低于对照组(P<0.05)。试验组各不良反应Ⅲ~Ⅳ度发生率低于对照组(P<0.05)。结论阶梯式营养干预可为胃癌术后化疗患者化疗提供充足的营养,改善机体免疫,减少不良反应或降低其严重程度,提高化疗耐受性。
Objective To study the effects of stepped nutrition intervention on chemotherapy tolerance,immune factors and adverse reactions in patients with gastric cancer undergoing postoperative chemotherapy.Methods A total of 106 patients with gastric cancer who received surgical treatment and postoperative chemotherapy in our hospital from July 2018 to June 2021 were selected and divided into Experimental group(n=53)and Control group(n=53)according to random number table method.Both groups received CAPEOX regimen chemotherapy,the Control group was given routine diet intervention after surgery,and the Experimental group was given routine diet intervention+stepped nutrition intervention.The chemotherapy tolerance of two groups was observed.Serum pre-albumin,albumin,total protein and other nutritional indicators,serum CD3;,CD4^(+),CD8^(+)and CD4^(+)/CD8^(+),other immune factors before and after intervention in the two groups,and adverse reactions.Results The good rate of chemotherapy tolerance in Experimental group was higher than that in Control group(P<0.05).After chemotherapy,the serum levels of pre-albumin,albumin and total protein in Experimental groups were higher than those in Control group(P<0.05).After chemotherapy,the levels of CD3;,CD4^(+)and CD4^(+)/CD8^(+)in Experimental groups were higher than those in Control group,and CD8^(+)was lower than that in Control group(P<0.05).The incidence of grade III-IV ADR in Experimental group was lower than that in Control group(P<0.05).Conclusion Stepped nutrition intervention can provide adequate nutrition for postoperative chemotherapy for patients with gastric cancer,improve chemotherapy tolerance,body immunity,and reduce adverse reactions or their severity.
作者
张晓萌
王晶晶
李笑敏
孙娟华
Zhang Xiaomeng;Wang Jingjing;Li Xiaomin(Department of oncology,the First Affiliated Hospital of Air Force Military Medical University,Xifan,Shanxi 710032,China)
出处
《四川医学》
CAS
2022年第3期279-283,共5页
Sichuan Medical Journal
关键词
阶梯式营养干预
胃癌
术后化疗
化疗耐受性
免疫因子
不良反应
stepped nutrition intervention
gastric cancer
postoperative chemotherapy
chemotherapy tolerance
immune factor
adverse reactions
