摘要
冠心病在临床心内科较为常见。经皮冠状动脉介入术(PCI)是临床上治疗冠心病的重要手段。对此病患者进行PCI时,常采用药物洗脱支架(DES)来扩张冠状动脉狭窄处。尽管DES的应用大幅度降低了支架内再狭窄(ISR)的发生率,但随着DES广泛应用于更多复杂冠状动脉病变(如冠状动脉左主干病变、冠状动脉分叉病变、冠状动脉慢性完全闭塞病变等)的治疗中,ISR的发生仍然是目前介入医生所面临的一个重要难题。现阶段临床上对于ISR的发生机制仍未完全明确,一般认为ISR的发生是一个与多种因素有关的复杂过程。本文就ISR发生机制、危险因素及防治措施方面的最新研究进展作一综述。
Coronary heart disease is common in clinical cardiology department.Percutaneous coronary intervention(PCI)is an important means of clinical treatment of coronary heart disease.Drug-eluting stents(DES)are often used to dilate coronary artery stenosis during PCI in these patients.Although the use of DES greatly reduces the incidence of stent restenosis(ISR),but with the wide application of DES on more complex coronary artery lesions(such as left main coronary artery disease,coronary artery bifurcation lesions,chronic totally occluded coronary artery pathological changes,etc.)of the treatment,the occurrence of ISR is still currently an important problem faced by cardiologists.At the present stage,the pathogenesis of ISR is still not completely clear in clinical practice,and it is generally believed that the occurrence of ISR is a complex process related to a variety of factors.This article reviews the recent progress in the pathogenesis,risk factors and prevention and treatment of ISR.
作者
罗娅
LUO Ya(Department of Cardiovascular Medicine,Guangxi Brain Hospital,Liuzhou G uangxi,545000)
关键词
经皮冠状动脉介入术
冠心病
药物洗脱支架
支架内再狭窄
percutaneous coronary intervention
Coronary heart disease(C HD)
Drug-eluting stents
Stent restenosis
