摘要
目的:探讨桂枝芍药知母汤加减治疗类风湿性关节炎的效果及对相关抗体水平的影响。方法:选取2018年10月-2020年6月瓦房店市中心医院骨科接收并诊疗的98例类风湿性关节炎患者,按照随机数字表法将其分为对照组和观察组,每组49例。对照组采用西医治疗,观察组在西医治疗基础上加用桂枝芍药知母汤加减,4周为1个疗程,共服用3个疗程。比较两组临床治疗效果;比较两组治疗前后红细胞沉降率(ESR)、C反应蛋白(CRP)、类风湿因子(RF)水平变化;比较两组治疗前后免疫功能抗体指标(血浆IgA、IgG、IgM)水平变化;比较两组治疗前后关节症状(关节压痛、关节肿胀、晨僵的严重程度)评分。结果:观察组总有效率为95.92%,高于对照组的81.63%,差异有统计学意义(P<0.05)。治疗前,两组IgA、IgG、IgM水平比较,差异均无统计学意义(P>0.05);治疗后,观察组IgA、IgG、IgM水平均低于对照组,差异均有统计学意义(P<0.05)。治疗前,两组ESR、CRP及RF水平比较,差异均无统计学意义(P>0.05);治疗后,观察组ESR、CRP及RF水平均低于对照组,差异均有统计学意义(P<0.05)。治疗前,两组关节压痛、关节肿胀、晨僵严重程度评分比较,差异均无统计学意义(P>0.05);治疗后,观察组关节压痛、关节肿胀、晨僵严重程度评分均低于对照组,差异均有统计学意义(P<0.05)。结论:桂枝芍药知母汤加减后用于类风湿性关节炎疾病中,与单纯西药治疗比较,临床疗效确切,患者的免疫功能增强,降低ESR、CRP和RF的水平,患者关节功能的恢复显著,是临床上值得推荐的中药治疗方剂。
Objective:To investigate the effect of Guizhi Shaoyao Zhimu Decoction in the treatment of rheumatoid arthritis and its influence on the levels of relevant antibodies.Method:A total of 98 rheumatoid arthritis patients admitted and treated in the Department of Orthopedics of Wafangdian Central Hospital from October 2018 to June 2020 were selected,they were divided into control group and observation group according to random number table method,with 49 cases in each group.The control group was treated with western medicine,and the observation group was treated with Guizhi Shaoyao Zhimu Decoction on the basis of western medicine,for a course of 4 weeks,a total of 3 courses.The clinical treatment effect was compared between two groups;erythrocyte sedimentation rate (ESR),C reactive protein (CRP) and rheumatoid factor (RF) levels before and after treatment were compared between two groups;the changes of immune function antibody indexes (plasma IgA,IgG,IgM) before and after treatment were compared between two groups;the scores of joint symptoms (joint tenderness,joint swelling,morning stiffness) before and after treatment were compared between two groups.Result:The total effective rate of the observation group was 95.92%,which was higher than 81.63% of the control group,the difference was statistically significant (P<0.05).Before treatment,there were no significant differences in IgA,IgG and IgM levels between two groups (P>0.05);after treatment,IgA,IgG and IgM levels of the observation group were lower than those of the control group,the differences were statistically significant (P<0.05).Before treatment,there were no significant differences in ESR,CRP and RF levels between two groups (P>0.05);after treatment,ESR,CRP and RF levels of the observation group were lower than those of the control group,the differences were statistically significant (P<0.05).Before treatment,there were no significant differences in joint tenderness,joint swelling and morning stiffness between two groups (P>0.05);after treatment,the severity
作者
刘晓丽
LIU Xiaoli(Wafangdian Central Hospital,Liaoning Province,Wafangdian 116300,China)
出处
《中国医学创新》
CAS
2022年第8期84-87,共4页
Medical Innovation of China
关键词
桂枝芍药知母汤
类风湿性关节炎
免疫功能
类风湿因子
关节肿胀
Guizhi Shaoyao Zhimu Decoction
Rheumatoid arthritis
Immune function
Rheumatoid factor
Joint swelling
