摘要
目的:观察丹参酮ⅡA磺酸钠注射液对慢性阻塞性肺疾病急性加重期(AECOPD)患者血流流变学及炎症状态的影响。方法:选取2018年11月-2019年10月在上海市奉贤区中心医院呼吸内科住院的136例AECOPD患者为研究对象,采用随机数字表法将其分为治疗组和对照组,各68例。两组均接受基础治疗,治疗组加用丹参酮ⅡA磺酸钠注射液治疗,对照组加用0.9%氯化钠注射液静滴,疗程14 d。比较两组血液流变学指标、肺功能、炎症指标及治疗效果。结果:治疗组血液流变学和血清炎症各指标治疗前后比较,差异均有统计学意义(P<0.05),对照组炎症指标治疗前后比较,差异均有统计学意义(P<0.05);治疗后,治疗组血液流变学和血清炎症指标均低于对照组,差异均有统计学意义(P<0.05)。治疗后,两组各项肺功能指标均较治疗前升高,且治疗组各项肺功能指标均高于对照组,差异均有统计学意义(P<0.05)。治疗组治疗总有效率为89.71%,高于对照组的72.06%,差异有统计学意义(P<0.05)。结论:在常规治疗基础上,加用丹参酮ⅡA磺酸钠注射液更有利于恢复AECOPD患者肺功能和提高治疗效果,可能与丹参酮ⅡA磺酸钠改善血液高凝状态和机体炎症状态有关。
Objective:To observe the effects of Tanshinone ⅡA Sodium Sulfonate Injection on hemorheology and inflammation in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD).Method:A total of 136 AECOPD patients hospitalized in Department of Respiratory Medicine,Shanghai Fengxian District Central Hospital from November 2018 to October 2019 were selected as the study subjects,they were divided into treatment group and control group by random number table method,68 cases in each group.Both groups received basic treatment,the treatment group was treated with Tanshinone ⅡA Sodium Sulfonate Injection,and the control group was treated with 0.9% Sodium Chloride Injection,the course of treatment was 14 d.Hemorheology,lung function,inflammation and therapeutic effect were compared between the two groups.Result:There were statistically significant differences in hemorheology and serum inflammation indexes before and after treatment in the treatment group (P<0.05),and there were statistically significant differences in inflammation indexes before and after treatment in the control group (P<0.05);after treatment,hemorheology and serum inflammation indexes in the treatment group were lower than those in the control group,the differences were statistically significant (P<0.05).After treatment,all lung function indexes in the two groups were higher than those before treatment,and all lung function indexes in the treatment group were higher than those in the control group,the differences were statistically significant (P<0.05).The total effective rate in the treatment group was 89.71%,higher than 72.06% in the control group,the difference was statistically significant (P<0.05).Conclusion:On the basis of conventional treatment,the addition of Tanshinone ⅡA Sodium Sulfonate Injection is more beneficial to restore lung function and improve the therapeutic effect of AECOPD patients,which may be related to the improvement of blood hypercoagulability and inflammation.
作者
沈魏
SHEN Wei(Shanghai Fengxian District Central Hospital,Shanghai 201499,China)
出处
《中国医学创新》
CAS
2022年第12期149-153,共5页
Medical Innovation of China
基金
奉贤区科委社会类科技发展基金项目(20181933)。
关键词
慢性阻塞性肺疾病
丹参酮ⅡA磺酸钠
肺功能
血流流变学
Chronic obstructive pulmonary disease
TanshinoneⅡA Sodium Sulfonate
Lung function
Hemorheology
