摘要
青光眼作为全球首位不可逆性致盲眼病,其视力丧失与房水排出通道受阻进而引起眼压升高导致视神经损伤有关。眼淋巴引流通路与房水排出系统的关系具有重要作用,探讨眼部淋巴管的生成发育以及明确眼部淋巴管的标志物对于研究青光眼房水流出是否包括淋巴管通路具有重要作用。房水排出系统与眼淋巴引流通路的关系:(1)小梁网内皮细胞中平足蛋白呈强阳性表达,而血小板-内皮细胞黏附分子(CD31)表达呈阴性,提示小梁网与淋巴管有密切关系;(2)Schelmm管与淋巴管具有形态学、分子学和功能上的相似性,不仅含有淋巴管和血管的一些特性,还存在一些在血管和淋巴管内皮细胞中均未发现的特性;(3)球结膜富含淋巴管,提示球结膜具有活跃的组织引流和免疫调节功能;(4)巩膜主要由胶原纤维构成,缺乏真正的淋巴管,但巩膜血管周围有较多淋巴管内皮透明质酸受体1(LYVE-1)阳性巨噬细胞,受到组织特异性因子的调节;(5)睫状体细胞中可以检测出多种淋巴标志物,电子显微镜下可观察到疑似淋巴管的通道;(6)脉络膜的单个细胞均表达多种淋巴标志物,LYVE-1表达最多。本文就淋巴管生成发育与淋巴标志物、房水流出组织的淋巴系统研究进展进行综述。
Glaucoma is the first irreversible blinding eye disease in the world,and vision loss due to glaucoma is related to the obstruction of the aqueous humor drainage channel,which leads to increased intraocular pressure and damage to the optic nerve.The relationship between the ocular lymphatic system and the aqueous humor drainage pathway is of important significance.Exploration of the generation and development of ocular lymphatic vessels and identification of the markers of ocular lymphatic vessels(LVs)are important for researching whether lymphatic pathways are involved in the aqueous humor outflow in glaucoma.Relationship between aqueous humor drainage system and ocular lymphatic drainage pathway can be elucidated from following aspects:(1)podoplanin is highly expressed in trabecular meshwork endothelial cells,while no expression of platelet-endothelial cell adhesion molecule(CD31)is found,suggesting that there is a close relationship between trabecular meshwork and LVs;(2)there are similarities in morphology,molecules and function between Schlemm canal and LVs,and Schlemm canal not only has some characteristics of LVs and blood vessels,but also some undiscovered characteristics of blood vessels and lymphatic endothelial cells;(3)the bulbar conjunctiva is rich in LVs,suggesting that the bulbar conjunctiva has active tissue drainage and immunoregulatory functions;(4)the sclera is mainly composed of collagen fibers and lacks real LVs,but many lymphatic vessel endothelial hyaluronic acid receptor 1(LYVE-1)-positive macrophages around the scleral vessels are regulated by tissue-specific factors;(5)multiple lymphatic markers can be detected in ciliary body,and suspected LVs can be observed by electron microscopy;(6)various lymphatic markers can be expressed in a single choroidal cell,with LYVE-1 expressed highest.Research progress in the lymphatic system of LVs,lymphatic markers,and aqueous humor outflow was reviewed in this article.
作者
刘雅萌(综述)
潘晓晶(审校)
Liu Yameng;Pan Xiaojing(State Key Laboratory Cultivation Base,Shandong Provincial Key Laboratory of Ophthalmology,Shandong Eye Institute,Shandong First Medical University&Shandong Academy of Medical Sciences,Qingdao Eye Hospital of Shandong First Medical University,Qingdao 266071,China)
出处
《中华实验眼科杂志》
CAS
CSCD
北大核心
2022年第4期361-365,共5页
Chinese Journal Of Experimental Ophthalmology
基金
山东省重点研发计划项目(2018GSF118103)
山东省医学科学院院级科技计划项目(2017-18)。
关键词
眼
房水
引流
淋巴管
Eye
Aqueous humor
Drainage
Lymphatic vessels
