摘要
目的:分析62例感染性腹泻患儿粪便标本中病原菌的分布及其耐药情况。方法:收集2019年2月—2020年7月来医院就诊的62例感染性腹泻患儿资料作为研究对象,留取患儿粪便作为标本,使用平板培养菌株,采用微生物动态检测系统辨别菌株类型,采用纸片扩散法进行药敏试验,分析粪便标本中病原菌分布及其耐药率。结果:62例感染性腹泻患儿粪便标本中分离出84株病原菌,主要为沙门菌属、志贺菌属、致病性大肠埃希菌、金黄色葡萄球菌和铜绿假单胞菌,占比分别为32.14%、28.57%、15.48%、13.10%、10.71%;沙门菌属中主要为04群、02群和07群,占比分别为13.09%、10.71%、8.33%;志贺菌属主要为福氏志贺菌、宋内志贺菌、鲍氏志贺菌、痢疾志贺菌,占比分别为10.71%、9.52%、7.14%、1.19%;沙门菌属对亚胺培南、阿米卡星的耐药率较低,分别为0.00%和3.70%;志贺菌属对亚胺培南、复方磺胺甲噁唑、阿米卡星的耐药率较低,分别为0.00%、0.00%、4.17%;致病性大肠埃希菌对亚胺培南的耐药率最低,为0.00%;金黄色葡萄球菌对亚胺培南的耐药率最低,为0.00%;铜绿假单胞菌对亚胺培南、阿米卡星的耐药率最低,分别为0.00%、0.00%。结论:沙门菌属、志贺菌属是引发儿童感染性腹泻的主要病原菌,且其主要菌株对常用抗菌药物有不同程度的耐药率;临床治疗时可据此制定相关措施,并积极采取预防控制措施,以有效地降低小儿感染性腹泻的发病率,促进患儿的康复。
Objective:To analyze the distribution and drug resistance of pathogenic bacteria in feces specimens of62 children with infective diarrhea.Methods:The data of 62 children with infectious diarrhea who were admitted to the hospital from February 2019 to July 2020 were collected as the research objects.The feces of the children were taken as specimens,and bacteria were cultured on a plate.The microbial dynamic detection system was used to identify the types of bacteria.The distribution and drug resistance rate of pathogenic bacteria in fecal specimens were analyzed.Results:A total of 84 strains of pathogenic bacteria were isolated from fecal specimens of 62 children with infectious diarrhea,mainly were Salmonella,Shigella,Escherichia coli,Staphylococcus aureus and Pseudomonas aeruginosa,accounting for 32.14%,28.57%,15.48%,13.10% and 10.71%,respectively.The main Salmonella groups were Salmonella 04,02and 07,accounting for 13.09%,10.71% and 8.33%,respectively.The main Shigella were Shigella flexneri,Shigella sonnei,Shigella baumannii and Shigella dysentery,accounting for 10.71%,9.52%,7.14% and 1.19%,respectively.The resistance rates of Salmonella to imipenem and amikacin were 0.00% and 3.70%,respectively.The drug resistance rates of Shigella to imipenem,compound sulfamethoxazole and amikacin were 0.00%,0.00% and 4.17%,respectively.The resistance rate of pathogenic Escherichia coli to imipenem was 0.00%.Staphylococcus aureus had the lowest resistance rate to imipenem,which was 0.00%.The resistance rates of Pseudomonas aeruginosa to imipenem and amikacin were 0.00% and 0.00%,respectively.Conclusion:Salmonella and Shigella are the main pathogenic bacteria causing infectious diarrhea in children,and the main strains have different resistance rates to commonly used antibiotics.In clinical treatment,relevant measures can be formulated,and prevention and control measures should be taken actively to effectively reduce the incidence of infective diarrhea in children and promote their recovery.
作者
张坤
ZHANG Kun(Wen County People's Hospital,Jiaozuo Henan 454850,China)
出处
《抗感染药学》
2022年第1期56-59,共4页
Anti-infection Pharmacy
关键词
儿童感染性腹泻
粪便标本
耐药性
沙门菌属
志贺菌属
pediatric infectious diarrhea
fecal specimen
drug resistance
Salmonella
Shigella
