摘要
肺炎克雷伯菌(Klebsiella pneumoniae,KP)是一种重要的肠杆菌科细菌,常定植于肠道与呼吸道,当机体抵抗力下降时引发疾病,也是引起院内和社区获得性感染的常见条件致病菌。近年来,KP致肝脓肿的发病率呈明显上升趋势,高毒力KP(hypervirulent KP,hvKP)因此受到广泛关注。hvKP从传统KP中分离出来,具有高毒力和高黏性等主要特征,可引发侵袭性感染,严重时可危及生命。为此,笔者综述了hvKP的流行病学、临床特征、主要毒力因子特征、临床诊治、耐药现状等,并对其研究进展做了分析。
Klebsiella pneumoniae(KP)is an important Enterobacteriaceae bacteria,which colonizes in the intestine and respiratory tract.It can cause diseases when the body’s resistance is reduced.KP is a common opportunistic pathogen that causes hospital-acquired and community-acquired infection.In recent years,the incidence of liver abscess caused by KP has shown a significant upward trend,so the hypervirulent KP(hvKP)has received widespread attention.hvKP is separated from traditional KP and has the main characteristics of hypervirulence and high viscosity,which can cause invasive infections and life-threatening in severe cases.In this article,the epidemiology,clinical characteristics,main virulence factors,clinical diagnosis and treatment,drug resistance status of hvKP are reviewed,and their research progress is analyzed.
作者
徐琴
XU Qin(Fengcheng People's Hospital,Fengcheng JiangXi 331100,China)
出处
《抗感染药学》
2022年第1期1-4,共4页
Anti-infection Pharmacy
关键词
肺炎克雷伯菌
高毒力
毒力因子
耐药性
肝脓肿
Klebsiella pneumoniae
hypervirulence
virulence factor
drug resistance
liver abscess
