摘要
痤疮是一种非常普遍的炎症性皮肤病,一直以来人们都认为它是由多种因素的相互作用发展而来。越来越多的证据表明,皮肤微生物群在其中占有至关重要的地位。痤疮丙酸杆菌的过度增殖长期以来被认为是导致痤疮的原因。然而,最近的研究表明皮肤微生物群失调才是导致痤疮发展的罪魁祸首。同时,肠道微生物群可能也参与痤疮的致病过程。本文主要综述了皮肤和肠道的微生物群与痤疮的关系,以及基于此的痤疮新疗法。
Acne is a highly prevalent inflammatory skin disease, which develops from an interplay of multiple factors. It is increasingly believed that the skin microbiome plays an important role in this disease. Over-proliferation of propionibacterium acnes has long been thought to contribute to the disease. However, recent studies indicate that the imbalance between different propionibacterium acnes phylotypes and the dysbiosis of skin microbiome is the key factor that leads to acne. Meanwhile, emerging evidences suggest that gut microbiota can be involved in the pathogenic process of acne. This review concentrates on the skin and gut microbes in acne and new microbiome-based therapies in treatment of acne.
作者
肖茗露
杨宇光
林碧雯
XIAO Minglu;YANG Yuguang;LIN Biwen(Department of Dermatology,the Fourth Medical Center,Chinese PLA General Hospital,Beijing 100048,China;Department of Dermatology,the First Medical Center,Chinese PLA General Hospital,Beijing 100853,China)
出处
《解放军医学院学报》
CAS
北大核心
2022年第2期231-234,共4页
Academic Journal of Chinese PLA Medical School
基金
北京市自然科学基金资助项目(7212097)。
