摘要
目的:探讨特发性肺间质纤维化患者预后不良的影响因素及预测价值。方法:选取60例特发性肺间质纤维化患者为研究对象,所有患者均接受吡非尼酮口服治疗,并根据治疗4个月后预后不同分为预后良好组(n=44)和预后不良组(n=16)。比较两组患者一般资料;多因素Logistic回归分析特发性肺间质纤维化患者预后不良的危险因素;受试者工作特征曲线(ROC)分析危险因素对预后不良的预测价值。结果:单因素分析发现,两组患者年龄、干咳、氧分压(PaO_(2))、肿瘤坏死因子α(TNF-α)、白细胞介素4(IL-4)和干扰素γ(IFN-γ)水平比较,差异有统计学意义(P<0.05)。多因素Logistic回归分析发现,PaO_(2)、TNF-α、IL-4、IFN-γ是特发性肺间质纤维化患者预后不良的危险因素(P<0.05)。ROC曲线分析显示,PaO_(2)、TNF-α、IL-4、IFN-γ曲线下面积(AUC)分别为0.831、0.875、0.901和0.855,其中IL-4预测价值较高(P<0.05),PaO_(2)、TNF-α和IFN-γ预测价值中等(P<0.05)。结论:PaO_(2)、TNF-α、IL-4、IFN-γ水平是特发性肺间质纤维化患者预后的危险因素,且具有较高的预后预测诊断价值。
Objective:To investigate the influencing factors and predictive value of poor prognosis in patients with idiopathic pulmonary interstitial fibrosis.Methods:60 patients with idiopathic pulmonary fibrosis were selected as the subjects.All patients were treated with oral pirfenidone,general information and the related clinical information collection,according to the different prognosis after 4 months of treatment,they were divided into good prognosis group(n=44)and poor prognosis group(n=16).The general data of the two groups were compared.Multivariate logistic regression analysis was used to explore the risk factors of poor prognosis in patients with idiopathic pulmonary fibrosis.The receiver operating characteristic curve(ROC)was drawn to analyze the predictive value of risk factors for poor prognosis.Results:Univariate analysis showed that age,dry cough,blood oxygen partial pressure(PaO_(2)),tumor necrosis factor(TNF-α),interleukin-4(IL-4)and Interferon-γ(IFN-γ)expression levels of the two groups were statistically significant(P<0.05).Multifactorial comparison showed that PaO_(2),TNF-α,IL-4 and IFN-γ were risk factors for poor prognosis in patients with idiopathic pulmonary interstitial fibrosis(P<0.05).ROC curve showed that the areas under the ROC curve for PaO_(2),TNF-α,IL-4 and IFN-γ were 0.831,0.875,0.901 and 0.855,respectively.Among them,IL-4 had higher diagnostic value.PaO_(2),TNF-α and IFN-γ the diagnostic value was medium(P<0.05).Conclusion:The levels of PaO_(2),TNF-α,IL-4 and IFN-γ are prognostic risk factors in patients with idiopathic pulmonary interstitial fibrosis,and have high diagnostic value.
作者
刘薇
张玲
鲍洁
高勇
LIU Wei;ZHANG Ling;BAO Jie;GAO Yong(First Department of Respiratory and Critical Care Medicine,Hebei Chest Hospital,Shijiazhuang 050000,Hebei,China)
出处
《川北医学院学报》
CAS
2022年第4期426-429,共4页
Journal of North Sichuan Medical College
基金
河北省医学科学研究课题计划项目(20211243)。
关键词
特发性肺间质纤维化
血氧分压
肿瘤坏死因子
白细胞介素-4
Γ-干扰素
Idiopathic pulmonary fibrosis
Blood oxygen partial pressure(PaO_(2))
Tumor necrosis factor
Interleukin-4(IL-4)
Interferon-γ(IFN-γ)
