摘要
黄曲霉毒素B1(AFB1)是当下所有已知的霉菌毒素中分布最广、最具代表性的毒素,具有强毒性、致癌性和致畸性。常见的饲料原料极易受到AFB1污染,严重危害动物健康,不仅给养殖生产带来重大经济损失,还会残留于动物产品中威胁人类健康。AFB1的毒性机制包括抑制动物生长发育、氧化应激、线粒体损伤、内质网应激、免疫毒性、细胞凋亡及脂质代谢紊乱等方面。文章对AFB1在体内的代谢过程及其毒性机制进行了综述。
Aflatoxin B1(AFB1) is the most widely distributed and most representative toxin among all known mycotoxins.It is highly toxic,carcinogenic,and teratogenic.Common feed ingredients are extremely susceptible to AFB1 pollution,which seriously endangers animal health.It not only brings significant economic losses to the production of breeding industry,but also further threatens human health by remaining in the animal products.The toxicity mechanism of AFB1 includes inhibition of animal growth and development,oxidative stress,mitochondrial damage,endoplasmic reticulum stress,immunotoxicity,cell apoptosis,and lipid metabolism disorder.The article reviewed the metabolic process in the body and the toxicity mechanism of AFB1.
作者
李民
孔祎頔
张雷
王桂芹
LI Min;KONG Yidi;ZHANG Lei;WANG Guiqin(College of Animal Science and Technology,Jilin Agricultural University,Ministry of Education Laboratory of Animal Production and Quality Security,Joint Laboratory of Modern Agricultural Technology International Cooperation,Jilin Provincial Key Laboratory of Animal Nutrition and Feed Science,Jilin Changchun 130118,China;Liaoning Agricultural and Animal Husbandry Machinery Research Institute Co.,Ltd.,Liaoning Shenyang 110036,China)
出处
《饲料工业》
CAS
北大核心
2022年第8期54-58,共5页
Feed Industry
基金
财政部和农业农村部:国家现代农业产业技术体系资助[CARS-46]
国家自然科学基金项目[31372540]。
关键词
黄曲霉毒素B1
代谢反应
毒性机制
氧化应激
内质网应激
aflatoxin B1
metabolic reaction
toxic mechanism
oxidative stress
endoplasmic reticulum stress
