摘要
目的探究丙泊酚复合依托咪酯全麻在四肢骨折患者中的临床应用效果。方法以随机抽样法为分组依据,将中国人民解放军联勤保障部队第九九零医院抽取的80例四肢骨折患者分为干预组(丙泊酚复合依托咪酯麻醉)与参照组(丙泊酚麻醉)各40例,均于2020年1月至2021年1月期间在本院接受治疗,对干预效果进行分析比较。结果两组T_(0)、T_(4)时间段平均动脉压(MAP)、心率(HR)、动脉血氧饱和度(SpO_(2))比较差异无统计学意义(P>0.05),干预组T_(1)、T_(2)、T_(3)时间段MAP、HR明显低于参照组,SpO_(2)高于对照组,差异有统计学意义(P<0.05),手术前两组白细胞介素-6(IL-6)、皮质醇(COR)、去甲肾上腺素(NE)比较,差异无统计学意义(P>0.05),手术后干预组各指标均低于参照组,差异有统计学意义(P<0.05),手术前两组急性简易智力状态(MMSE)评分比较,差异无统计学意义(P>0.05),手术后干预组评分高于参照组,另外干预组躁动评分低于参照组,差异有统计学意义(P<0.05)。结论丙泊酚复合依托咪酯全麻能减轻术后应激反应,避免术后躁动,还可稳定患者血流动力学指标,对认知功能的影响较小。
Objective To explore the clinical effect of propofol compound etomidate general anesthesia in patients with limb fractures.Method Based on random sampling method,A total of the 80 cases of limb fracture patients treated in Chinese people’s liberation army joint logistic support unit 990 hospital from January 2020 to January 2021 were divided into intervention group(propofol compound etomidate anesthesia)40 cases and reference group(propofol anesthesia)40 cases,the intervention effect were compared.Results The mean arterial pressure(MAP),heart rate(HR),arterial oxygen saturation(SpO_(2))between two groups in T_(0) and T_(4) had no significant differences(P>0.05).MAP and HR in T_(1),T_(2) and T_(3) in intervention group were significantly lower than the reference group,and SpO_(2) was higher than the reference group,statistically significant(P<0.05).Before the operation,the interleukin-6(IL-6),cortisol(COR)and norepinephrine(NE)had no differences between two groups(P>0.05),after operation,each index in intervention group was lower than the reference group,with significant differences(P<0.05).There was no difference in acute simple mental status(MMSE)scores between the two groups before the operation(P>0.05),after surgery,the intervention group score was higher than the reference group,and the intervention group agitation score was lower than the reference group,which was statistically significant(P<0.05).Conclusion Propofol can reduce postoperative stress response,avoid postoperative agitation,stabilize patient hemodynamic index and has less effect on cognitive function.
作者
李祯
黄杰
LI Zhen;HUANG Jie(Department of Anesthesiology,The 990th Hospital,Joint Logistic Support Force of the Chinese People’s Liberation Army,Zhumadian Henan 463000,China)
出处
《临床研究》
2022年第3期67-71,共5页
Clinical Research
关键词
四肢骨折
丙泊酚
依托咪酯
应激反应
认知功能
limb fracture
propofol
etomidate
stress response
cognitive function
