摘要
目的利用静息态功能磁共振成像(resting-state functional magnetic resonance imaging,rs-fMRI)技术功能连接和局部一致性(regional homogeneity,ReHo)的方法探讨梅尼埃病患者静息态脑活动的变化。材料与方法选取梅尼埃病发作期患者12例和健康对照组12例,进行rs-fMRI扫描,基于REST-plus软件,以双侧丘脑为感兴趣区,比较两组脑功能连接差异;运用肯德尔一致系数局部一致性(Kendall′s coefficient concordance regional homogeneity,KCC-ReHo)和相干性局部一致性(coherence regional homogeneity,Cohe-ReHo)两种方法分析数据,比较两组受试者的ReHo值。结果梅尼埃病患者组双侧丘脑和右侧额下回功能连接增强;KCC-ReHo增高的脑区主要位于左侧颞下回,减低的脑区主要位于右侧额上回;Cohe-ReHo增高的脑区主要位于右侧小脑、左侧颞下回,减低的脑区主要位于右侧额上回、右顶上回、右侧楔前叶(Alphasim校正,校正后P<0.05)。结论静息状态下梅尼埃病患者脑功能连接和ReHo值均发生改变,主要涉及中枢前庭系统和视觉皮层相关脑区,可能与梅尼埃病的发病机制有关。
Objective:To investigate the alterations of functional connectivity(FC)and regional homogeneity(Re Ho)by the resting-state functional magnetic resonance imaging(rs-f MRI)in patients with Ménière disease(MD).Materials and Methods:A total of 12 patients with active MD and 12 healthy control subjects were enrolled to rs-f MRI scan.Seed-based functional connectivity analysis of bilateral thalamus was performed using the REST-plus software.The data were analyzed to evaluate the differences in Re Ho values between the two groups by the Kendall’s coefficient concordance regional homogeneity(KCC-Re Ho)and coherence regional homogeneity(Cohe-Re Ho).Results:Compared with the healthy control group,the increased connectivity of right thalamus and right inferior frontal gyrus was showed in MD patients.KCC-Re Ho in MD patients were higher in the left inferior temporal gyrus,lower in the right superior frontal gyrus;Cohe-Re Ho in MD patients was higher in the right cerebellum and the left inferior temporal gyrus,lower in the right parietal superior gyrus,right superior frontal gyrus,and left precuneus(corrected by Alphasim,P<0.05 after correction).Conclusions:This study identified specific alterations of FC and Re Ho values in patients with MD,which may relate to the pathogenesis of Meniere’s disease.
作者
袁小佳
李小圳
徐彧
杨燕
刘蕾
王伟涛
赵思敏
杜丰夷
钟利群
陈正光
赵天佐
YUAN Xiaojia;LI Xiaozhen;XU Yu;YANG Yan;LIU Lei;WANG Weitao;ZHAO Simin;DU fengyi;ZHONG Liqun;CHEN Zhengguang;ZHAO Tianzuo(Department of Radiology,Dongzhimen Hospital,Beijing University of Chinese Medicine,Beijing 100700,China;Department of Neurology,Dongzhimen Hospital,Beijing University of Chinese Medicine,Beijing 100700,China)
出处
《磁共振成像》
CAS
CSCD
北大核心
2022年第4期75-78,共4页
Chinese Journal of Magnetic Resonance Imaging
关键词
梅尼埃病
静息态功能磁共振成像
功能连接
局部一致性
Ménière disease
resting-state functional magnetic resonance imaging
regional homogeneity
functional connectivity
