摘要
目的探讨健脾益胃方治疗脾胃气虚型消化性溃疡的临床效果。方法选取2019年9月至2021年2月在广西中医药大学附属国际壮医医院脾胃肝病科接受治疗的脾胃气虚型消化性溃疡患者90例作为研究对象,采用随机数字表法分为对照组和治疗组,每组各45例。对照组予常奥美拉唑肠溶胶囊治疗,治疗组在对照组的基础上加用健脾益胃方,进行为期4周的临床疗效观察。观察并记录两组治疗前后胃蛋白酶原(PG)Ⅰ、PGⅡ、PGⅠ/PGⅡ比值的变化情况及不良事件。结果治疗组临床疗效优于对照组(P<0.05)。治疗后两组PGⅠ低于治疗前,且治疗组低于对照组(P<0.05);治疗后治疗组PGⅡ低于治疗前,且治疗组低于对照组(P<0.05)。两组在治疗过程中均无皮疹、恶心呕吐、晕针等不良反应。结论健脾益胃方可以有效抑制PGⅠ、PGⅡ表达,改善胃肠蠕动功能,对脾胃气虚型消化性溃疡疗效确切,且无不良反应,值得临床借鉴、推广及应用。
Objective To explore the clinical effect of Jianpi Yiwei Formula in the treatment of peptic ulcer with the syndrome of deficiency of spleen and stomach.Methods A total of 90 patients of peptic ulcer with the syndrome of deficiency of spleen and stomach who were treated in Department of Spleen-stomach Liver Disease in the International Zhuang Medical Hospital Affiliated to Guangxi University of Chinese Medicine from September 2019 to February 2021 were divided into the control group and the treatment group by random number table method,45 cases in each group.The control group was given Omeprazole Enteric-coated Capsules.The treatment group was treated with Jianpi Yiwei Formula on the basis of the control group.The clinical efficacy was observed for four weeks.The changes situation of pepsinogen(PG)Ⅰ,PGⅡ,and the PGⅠ/PGⅡ before and after treatment,the adverse events in the two groups were observed and recorded.Results The clinical effect of the treatment group was better than that in the control group(P<0.05).After treatment,PGⅠin the two groups were lower than those before treatment,and the treatment group was lower than that in the control group(P<0.05).After treatment,PGⅡ in the treatment group was lower than that before treatment,and PGⅡ in the treatment group was lower than that in the control group(P<0.05).There were no adverse reactions such as rash,nausea and vomiting,and needlesickness in the both groups.Conclusion Jianpi Yiwei Formula can effectively inhibit the expression of PGⅠ and PGⅡ,and improve the function of gastrointestinal peristalsis,and has definite effect of peptic ulcer with the syndrome of deficiency of spleen and stomach,there is no adverse reaction,it is worthy of reference,promotion,and application in clinic.
作者
蒋玉萍
刘伟锋
温智稀
吴姗姗
段桂姣
吕艳杭
JIANG Yuping;LIU Weifeng;WEN Zhixi;WU Shanshan;DUAN Guijiao;LYU Yanhang(The Second Department of Internal Medicine,Mingxiu Branch of International Zhuang Medical Hospital Affiliated to Guangxi University of Chinese Medicine,Guangxi Zhuang Autonomous Region,Nanning 530001,China;Department of Spleen-stomach Liver Disease,International Zhuang Medical Hospital Affiliated to Guangxi University of Chinese Medicine,Guangxi Zhuang Autonomous Region,Nanning 530200,China;Graduate School,Guangxi University of Chinese Medicine,Guangxi Zhuang Autonomous Region,Nanning 530001,China)
出处
《中国医药导报》
CAS
2022年第10期144-146,162,共4页
China Medical Herald
基金
广西壮族自治区中医药管理局科研课题(GZZC2020137)
广西壮族自治区中医药局科研课题(GZZC2019013)
广西中药药效研究重点实验室课题(20-065-38)。
关键词
健脾益胃方
消化性溃疡
疗效
Jianpi Yiwei Formula
Peptic ulcer
Curative effect
