摘要
子痫前期是涉及多系统损害的妊娠期特有疾病,是孕产妇和围生儿死亡的主要原因之一,严重威胁母儿健康。子痫前期的不良宫内环境易导致胎儿生长受限、早产和低出生体质量儿等不良结局,其发病机制尚不十分明确。子痫前期可以过度激活氧化应激和炎症反应,同时可能诱导表观遗传修饰改变,使子代在生长发育过程中心血管系统重构,损害心血管结构与功能,增加子代成年后罹患心血管疾病的风险。综述子痫前期的不良宫内环境导致子代心血管疾病的可能机制及子代心血管系统结构和功能的改变,以期了解胎源性心血管疾病的发生、发展,有助于疾病的早期干预和阻断,提高子痫前期子代的生命健康水平。
Pre-eclampsia is an idiopathic disease during pregnancy that causes multisystem damage and is one of the leading causes of maternal and perinatal mortality,posing a serious threat to maternal and neonatal health.The adverse intrauterine environment in pre-eclampsia predisposes to adverse neonatal outcomes such as intrauterine growth retardation,preterm birth,and low birth weight.The pathogenesis is not fully understood but exaggerated oxidative stress and inflammatory responses are involved in it.And pre-eclampsia may induce altered epigenetic modifications in the offspring,resulting in cardiovascular system remodeling during growth and development and impairing cardiovascular structure and function,which would increase the risk of cardiovascular disease in adult offspring.This article reviews the possible mechanisms of cardiovascular disease in the offspring due to adverse intrauterine environment in pre-eclampsia and the alterations in cardiovascular structure and function in the offspring,with the aim of understanding the development of fetal-derived cardiovascular disease,contributing to early intervention and interruption of the disease,and improving the health of the offspring delivered by pregnancy complicated with pre-eclampsia.
作者
陈慧赟
韩冰(审校)
陈友国
CHEN Hui-yun;HAN Bing;CHEN You-guo(The First Affiliated Hospital of Soochow University,Suzhou 215006,Jiangsu Province,China)
出处
《国际妇产科学杂志》
CAS
2022年第2期125-128,共4页
Journal of International Obstetrics and Gynecology
基金
江苏省卫生健康委科研项目(H2019010)。
关键词
先兆子痫
心血管疾病
后成说
遗传
心室重构
早产
Pre-eclampsia
Cardiovascular diseases
Epigenesis,genetic
Ventricular remodeling
Premature birth
