摘要
目的 综述原位3D生物打印技术在骨和软骨损伤修复方面的研究进展。方法 查阅近年国内外原位3D生物打印技术用于骨和软骨损伤修复的相关文献,并进行分析和总结。结果 原位3D生物打印作为一种新兴的组织工程技术,主要应用于骨、软骨和皮肤等组织损伤修复。通过将生物材料、生物活性物质与细胞相结合,在损伤或缺损部位直接打印移植体修复缺损。目前关于打印技术的研究主要集中于打印模式、生物墨水和打印技术等方面;骨及软骨领域应用研究主要集中在预血管化,调整生物墨水组成,改善支架结构、打印技术,负载药物、细胞和生物活性因子等,以促进组织损伤修复。结论 原位3D生物打印可以实时快速并且微创化构建骨和软骨组织移植体,未来需要继续研制适合特定组织移植体的生物墨水,以及与机器人技术、融合成像、计算机辅助医疗相结合,提升打印效率。
Objective To review the research progress of in-situ three dimensional(3D) bio-printing technology in the repair of bone and cartilage injuries. Methods Literature on the application of in-situ 3D bio-printing technology to repair bone and cartilage injuries at home and abroad in recent years was reviewed, analyzed, and summarized.Results As a new tissue engineering technology, in-situ 3D bio-printing technology is mainly applied to repair bone,cartilage, and skin tissue injuries. By combining biomaterials, bioactive substances, and cells, tissue is printed directly at the site of injury or defect. At present, the research on the technology mainly focuses on printing mode, bio-ink, and printing technology;the application research in the field of bone and cartilage mainly focuses on pre-vascularization,adjusting the composition of bio-ink, improving scaffold structure, printing technology, loading drugs, cells, and bioactive factors, so as to promote tissue injury repair. Conclusion Multiple animal experiments have confirmed that in-situ 3D bio-printing technology can construct bone and cartilage tissue grafts in a real-time, rapid, and minimally invasive manner. In the future, it is necessary to continue to develop bio-inks suitable for specific tissue grafts, as well as combine with robotics, fusion imaging, and computer-aided medicine to improve printing efficiency.
作者
裴志伟
王建忠
PEI Zhiwei;WANG Jianzhong(Department of Orthopedics,the Second Affiliated Hospital of Inner Mongolia Medical University,Hohhot Inner Mongolia,010000,P.R.China)
出处
《中国修复重建外科杂志》
CAS
CSCD
北大核心
2022年第4期487-494,共8页
Chinese Journal of Reparative and Reconstructive Surgery
关键词
原位3D生物打印技术
骨修复
软骨修复
组织工程
In-situ three-dimensional bio-printing technology
bone repair
cartilage repair
tissue engineering
