摘要
目的探讨支气管镜冷冻肺活检联合血清CC趋化因子受体3(CCR3)、乳酸脱氢酶(LDH)、白介素33(IL-33)对周围型肺癌检出率及病理分型判断的价值。方法选取78例确诊为周围型肺癌的患者,经病理检查出腺癌39例、鳞癌19例、小细胞癌12例、其他类型肺癌8例。对患者进行支气管镜冷冻肺活检,并检测其血清CCR3、LDH、IL-33水平;分析各检测方法单独及联合检测对不同病理分型与病灶大小的阳性检出率。结果经支气管镜冷冻肺活检、血清CCR3、LDH、IL-33及其联合检测的阳性检出率分别为82.05%、62.82%、58.97%、51.28%、92.31%,经支气管镜冷冻肺活检联合血清CCR3、LDH、IL-33的检出率高于单独检查(P<0.05)。支气管镜冷冻肺活检联合血清CCR3、LDH、IL-33对腺癌、鳞癌、小细胞癌及其他类型肺癌的阳性检出率高于单独检测(P<0.05)。支气管镜冷冻肺活检联合血清CCR3、LDH、IL-33对病灶直径<2 cm、2~6 cm、>6 cm的阳性检出率高于单独检测(P<0.05)。结论支气管镜冷冻肺活检联合血清CCR3、LDH、IL-33检测周围型肺癌相对于单项检查,具有更高的检出率,病理分型判断更准确,推荐临床使用。
Objective To investigate the value of transbronchial lung cryobiopsy combined with serum CC chemokine receptor 3(CCR3),lactate dehydrogenase(LDH)and interleukin 33(IL-33)in the detection and pathological classification of peripheral lung cancer.Methods 78 patients with peripheral lung cancer were enrolled,and pathological results indicated 39 cases of adenocarcinoma,19 cases of squamous cell carcinoma,12 cases of small cell carcinoma and 8 cases of other types of lung cancer.Transbronchial lung cryobiopsy,and detection of serum CCR3,LDH and IL-33 were performed,respectively.Results The detection rates of transbronchial lung biopsy,serum CCR3,LDH,and IL-33 were 82.05%,62.82%,58.97%and 51.28%,respectively,while the detection rate of combined detection was 92.31%,indicating that the detection rate of combined examination of transbronchial lung biopsy,serum CCR3,LDH,and IL-33 was significantly higher than that of single examination(P<0.05).The detection rates of adenocarcinoma,squamous cell carcinoma,small cell carcinoma and other types of lung cancer through combined examination of transbronchial lung biopsy,serum CCR3,LDH,and IL-33 were significantly higher than those through single examination(P<0.05).Combined examination of transbronchial lung biopsy,serum CCR3,LDH,and IL-33 had higher detection rate for lesion diameters<2cm,2~6cm,and>6cm than that of single examination(P<0.05).Conclusion Compared with single examination,combined examination of transbronchial lung biopsy,serum CCR3,LDH,and IL-33 shows a higher detection rate and accuracy in pathological classification of peripheral lung cancer,which is worthy of recommendation.
作者
康贝贝
KANG Beibei(Zhoukou Central Hospital,Zhoukou,466000)
出处
《实用癌症杂志》
2022年第4期622-625,共4页
The Practical Journal of Cancer
基金
河南省教育厅科研计划(编号:21A320001)。
关键词
支气管镜冷冻肺活检
CC趋化因子受体3
乳酸脱氢酶
白介素33
周围型肺癌
检出率
病理分型
Transbronchial lung cryobiopsy
CC chemokine receptor 3
Lactate dehydrogenase
Interleukin 33
Peripheral lung cancer
Detection rate
Pathological classification
