摘要
目的:探讨64排螺旋CT灌注成像参数联合血清肿瘤标志物对孤立性肺结节性质的鉴别价值。方法:收治某院86例孤立性肺结节患者,先予以所有患者开展64排螺旋CT灌注成像参数(单独组),再予以患者血清肿瘤标志物检测(联合组)。分析64排螺旋CT灌注成像参数联合血清肿瘤标志物临床应用价值。结果:联合组恶性结节诊断准确率86.67%与良性结节诊断准确率92.86%均高于单独组恶性结节诊断准确率63.33%与良性结节诊断准确率78.57%(P<0.05)。64排螺旋CT灌注成像扫描期间,恶性结节患者在扫描21s、23s、25s、27s、29s、31s、33s与35s的强化值均低于良性结节患者(P<0.05)。35s时,良性结节无强化占比33.93%高于恶性结节无强化0.00%,良性结节在不全强化中占比46.43%高于恶性结节不全强化6.67%,良性结节完全强化占比19.64%低于恶性结节完全强化93.33%,互比有差异性(P<0.05)。良恶性结节在表面渗透性、血流量、血容积与Patlak血容积参数值方面互比无差异性(P>0.05);恶性结节Patlak方程灌注参数值高于良性结节(P<0.05)。恶性结节癌胚抗原、糖链抗原125、细胞角蛋白19片段与神经特异性烯醇化酶指标均高于良性结节(P<0.05)。结论:64排螺旋CT灌注成像参数联合血清肿瘤标志物对孤立性肺结节性质的鉴别价值高,值得推广。
Objective:To explore the value of 64-slice spiral CT perfusion imaging parameters combined with serum tumor markers in the differentiation of solitary pulmonary nodules.Methods:86 patients with solitary pulmonary nodules admitted to a hospital were selected.All patients were first treated with 64-slice spiral CT perfusion imaging parameters(single group),and then patients'serum tumor markers were detected(combined group).The clinical application value of 64-slice spiral CT perfusion imaging parameters combined with serum tumor markers was analyzed.Results:The diagnostic accuracy of malignant nodule and benign nodule were 86.67%and 92.86%in the combined group,which were higher than those in the single group(63.33%and 78.57%)(P<0.05).During 64-slice spiral CT perfusion imaging,the enhancement values of patients with malignant nodules at 21s,23s,25s,27s,29s,31s,33s and 35s were lower than those of patients with benign nodules(P<0.05).At 35s,the proportion of non-enhanced benign nodules was 33.93%,higher than that of non-enhanced malignant nodules(0.00%),the proportion of incomplete enhancement of benign nodules was 46.43%,higher than that of incomplete enhancement of malignant nodules(6.67%),and the proportion of complete enhancement of benign nodules was 19.64%,lower than that of complete enhancement of malignant nodules(93.33%),showing difference between each other(P<0.05).There was no difference between benign and malignant nodules in surface permeability,blood flow,blood volume and Patlak blood volume parameters(P>0.05).The value of Patlak equation perfusion parameters of malignant nodules was higher than that of benign nodules(P<0.05).The levels of carcinoembryonic antigen,glycochain antigen 125,cytokeratin 19 fragment and neurospecific enolase of malignant nodules were higher than those of benign nodules(P<0.05).Conclusion:The perfusion imaging parameters of 64-slice spiral CT combined with serum tumor markers are of high value in the differentiation of solitary pulmonary nodules,which is worthy of promotion.
作者
盛向前
杨红卫
Sheng Xiangqian;Yang Hongwei(CT Room,Mengjin People's Hospital,Luoyang 471100)
出处
《数理医药学杂志》
CAS
2022年第4期493-496,共4页
Journal of Mathematical Medicine
关键词
血清肿瘤标志物
64排螺旋CT灌注成像参数
孤立性肺结节性质
良性
恶性
serum tumor markers
perfusion imaging parameters of 64-slice spiral CT
the nature of solitary pulmonary nodules
benign
malignant
