摘要
目的:研究血清胆红素水平与稳定型心绞痛(SAP)和急性心肌梗死(AMI)患病风险的关系。方法:我院的冠心病患者266例被选为冠心病组,依据疾病类型,冠心病组被分为AMI组(114例)和SAP组(152例),另选择同期健康体检者837例为健康对照组。比较各组间一般临床资料。根据血清总胆红素(TBIL)、直接胆红素(DBIL)水平,又各分三层次,分析血清胆红素水平与冠心病患病风险的关系。结果:与健康对照组比较,冠心病组吸烟史、糖尿病比例、血清总胆固醇、低密度脂蛋白水平均显著升高,血清高密度脂蛋白水平显著降低(P均<0.01)。多因素Logistic回归分析显示:血清DBIL为冠心病的SAP、AMI的独立保护因素(OR=0.45~0.72,P均=0.001),血清TBIL为SAP的独立保护因素(OR=0.94,P=0.001);血清DBIL水平越高,冠心病的SAP、AMI患病风险越低(OR=0.09~0.72,P均<0.01);血清TBIL水平越高,冠心病的SAP患病风险越低(OR=0.43~0.94,P<0.05或<0.01);血清DBIL水平每升高1μmol/L,冠心病患病风险下降42%;血清DBIL水平每增加1μmol/L,AMI患病风险下降28%;血清TBIL、DBIL水平每增加1μmol/L,SAP患病风险分别下降6%。结论:血清胆红素水平越高,稳定型心绞痛和急性心肌梗死患病风险越低。
Objective:To study relationship among serum bilirubin level and risk of stable angina pectoris(SAP)and acute myocardial infarction(AMI).Methods:A total of 266 patients with coronary heart disease(CHD)treated in our hospital were selected as CHD group.According to disease type,CHD group was divided into AMI group(n=114)and SAP group(n=152).Another 837 healthy volunteers were simultaneously regarded as healthy control group.General clinical data were compared among all groups.According to serum levels of total bilirubin(TBIL)and direct bilirubin(DBIL),each were divided into 3 gradation again and relationship among serum bilirubin level and risk of CHD was analyzed.Results:Compared with healthy control group,there were significant rise in percentages of smoking history and diabetes mellitus,serum levels of total cholesterol and low-density lipoprotein,and significantly reduction in serum high-density lipoprotein level in CHD group(P<0.01 all).Multivariate Logistic regression analysis indicated that serum DBIL was an independent protective factor for SAP and AMI(OR=0.45~0.72,P=0.001 all),and serum TBIL was an independent protective factor for SAP(OR=0.94,P=0.001);higher serum DBIT level led to lower risk of SAP and AMI(OR=0.09~0.72,P<0.01 all),and higher serum TBIT level led to lower risk of SAP(OR=0.43~0.94,P<0.05 or<0.01);serum DBIT level increased by 1μmol/L,risk of CHD decreased by 42%;serum DBIT level increased by 1μmol/L,risk of AMI decreased by 28%;serum levels of TBIT and DBIT increased by 1μmol/L,risk of SAP decreased by 6%respectively.Conclusion:Higher serum bilirubin level are associated with lower risk of SAP and AMI.
作者
赵燕
任芳
刘雪侠
ZHAO Yan;REN Fang;LIU Xue-xia(Department of Cardiology,People's Hospital of Jieshou City,Jieshou,Anhui,236500,China)
出处
《心血管康复医学杂志》
CAS
2022年第2期175-179,共5页
Chinese Journal of Cardiovascular Rehabilitation Medicine
关键词
冠心病
胆红素
心绞痛
稳定型
Coronary disease
Bilirubin
Angina,stable
