摘要
目的基于本草古籍毒性分类对现有中药毒性分级方法提出改进意见。方法采用文献学研究方法梳理历代本草古籍对中药毒性的论述,厘清中药毒性概念的起源、中药毒性分级的演变过程以及影响中药毒性的主要因素。结果历代中药毒性的分级经历了三品分类、四级分类、五级分类法,不同的基原、炮制、服法及患者体质的差异皆会影响药物的毒性。结论应从药材性质、临床应用两个维度,构建一个多层级、多因素的中药毒性评价体系。药材性质包括药物的基原植物、药用部位、炮制方法的细化,临床应用包括给药方式、时间、剂量以及患者体质因素对药品不良反应的影响。
Objective To propose ways of improving the current methods of toxicity classification of traditional Chinese medicine(TCM)based on the review of ancient records of toxicity of Chinese herbal medicines.Methods The literature research method was used to search for literature related to the toxicity of TCM in ancient Chinese herbal books and to clarify concepts of T CM toxicity,the evolution of toxicity classification of TCM,and the main determinants of the toxicity of TCM.Results The classification of the toxicity of TCM has undergone three-level classification,four-level classification,and five-level classification.The difference in genes,preparations,medications,and physique of patents will affect the toxicity of TCM.Conclusion A multi-level and multi-factor toxicity evaluation system for TCM should be established,involving the source of the medicine,methods of preparation,the time and dosage of the medicine used,and the condition of the patient.
作者
付璐
金艳
彭华胜
袁媛
FU Lu;JIN Yan;PENG Huasheng;YUAN Yuan(National Resource Center for Chinese Materia Medica,China Academy of Chinese Medical Science,Beijing 100700,China;Postdoctoral Research Station of China Academy of Chinese Medical Science,Beijing 100700,China)
出处
《中国药物警戒》
2022年第4期349-352,共4页
Chinese Journal of Pharmacovigilance
基金
国家重点研发计划(2020YFE0205100)
国家科技基础资源调查专项(2018FY100800)
中央本部级重大支减项目(2060302)
中央级公益性科研院所基本科研业务费专项资金资助(ZZ10-008)
中国中医科学院中药资源中心自主选题(zzxt202107)。
关键词
中药毒性
中药毒性分级
本草古籍
toxicity of Chinese materia medica
toxicity classification of Chinese materia medica
ancient books of materia medica
