摘要
随着纳米技术和纳米医学的快速发展,量子点(quantum dots,QDs)作为一种新型的荧光材料在生物医学领域具有广阔的应用前景,其对免疫系统的影响也引起关注。体内外的研究结果表明,QDs可以被免疫细胞内化,进入免疫细胞后可以诱导自噬效应的发生,影响免疫细胞的分化发育,进而影响免疫应答,表现为对炎症反应的调节,而诱导自噬产生的机制研究集中于氧化应激水平的变化。我们通过对QDs免疫毒性及其机制的综述,旨在为QDs的生物安全性研究和开拓其应用前景提供实验室参考依据。
With the rapid development of nanotechnology and nanomedicine,quantum dots(QDs) as a new type of fluorescent material have promising applications in the biomedical field.Their effects on the immune system have also attracted attention.In vitro and in vivo studies have shown that QDs can be internalized by immune cells and can induce autophagy after entering immune cells,affecting the differentiation and development of immune cells,which in turn affects the immune response,manifesting as a regulation of the inflammatory response.In contrast,studies on the mechanisms that induce autophagy production have focused on changes in oxidative stress levels.By summarizing the immunotoxicity of QDs and the underlying mechanisms,the aim is to provide a laboratory reference for biosafety studies of QDs and to develop their application prospects.
作者
缪雪峰
黎雪梅
姚钢
章科
MIAO Xue-feng;LI Xue-mei;YAO Gang;ZHANG Ke(Jiangsu Zhongzhisheng Environmental Technology Co.,Ltd.,Suzhou Jiangsu,215519,China)
出处
《职业与健康》
CAS
2022年第4期568-571,共4页
Occupation and Health
关键词
量子点
免疫毒性
自噬
氧化应激
Quantum dots
Immunotoxicity
Autophagy
Oxidative stress
