摘要
目的:了解我院分枝杆菌的分离情况及耐药性特点。方法:采用银科医学工程有限公司提供的分枝杆菌配套试剂,对我院2019—2020年送检的痰和灌洗液等标本进行培养鉴定和药敏试验。结果:总共分离分枝杆菌869例,主要集中在41~60岁和61~80岁年龄段。结核分枝杆菌755例,耐药率较高的有链霉素(43.2%)、异烟肼(41.3%)和利福平(34.3%)。非结核分枝杆菌114例,检出较多的有胞内分枝杆菌、龟脓肿分枝杆菌、鸟分枝杆菌和堪萨斯分枝杆菌;耐药率小于30%的有阿米卡星、莫西沙星、利福布汀、头孢西丁和克拉霉素。结论:分枝杆菌耐药性严重,非结核分枝杆对常规抗结核药物已基本失效;在非结核分枝杆菌新药敏套餐中,不同的非结核分枝杆菌对药物耐药性差异较大,药敏试验对临床用药有重要的指导意义。
Objective:To understand the isolation and drug resistance of Mycobacterium in our hospital.Methods:The sputum and lavage fluid from 2019 to 2020 in our hospital were cultured,identified and tested for drag sensitivity by using the kit reagent of Mycobacterium provided by Yinke Medical Engineering CO.Results:A total of 869 cases of Mycobacterium were isolated,mainly in 41-60 and 61-80 years of age.There were 755 cases of M.tuberculosis,among which Streptomycin(43.2%),Isoniazid(41.3%)and Rifampin(34.3%)were the most resistnat.There were 114 cases of nontuberculosis mycobacterium,the most common islates were M.intracellulare,M.chelonae/abscessus,M.avium and M.kansasii;the resistance rates of less than 30%were Amikacin,Moxifloxacin,Rifabutin,Cefoxitin and Clarithromycin.Conclusion:The drug resistance of Mycobacterium in our hospitan is serious,nontuberculosis mycobacterium has basically failed to conventional Tuberculosis management;in the drug sensitive package of nontuberculosis mycobacterium,the drug resistance of different nontuberculosis mycobacterium is quite different to different drugs,drug sensitivity test has important guiding significance for clinical drug use.
作者
宋育明
杨映晖
董春萍
SONG Yuming;YANG Yinghui;DONG Chunping(Xinglin Laboratory,the First Affiliated Hospital of Xiamen University,Xiamen,Fujian 361022,China)
出处
《中国药物滥用防治杂志》
CAS
2022年第2期240-244,259,共6页
Chinese Journal of Drug Abuse Prevention and Treatment
关键词
结核分枝杆菌
非结核分枝杆菌
肺病
耐药性
M.tuberculosis
Nontuberculosis Mycobacterium
Lung Disease
Drug Resistance
