摘要
目的:分析中药保留灌肠治疗恶性肠梗阻(Malignant Bowel Obstruction,MBO)的用药规律,为临床组方用药提供参考。方法:于中国期刊全文数据库、万方数据库、维普中文期刊平台检索2008年1月-2021年5月使用中药保留灌肠治疗MBO的相关文献,将符合条件的文献中所使用的中药录入Excel 2019,建立数据库。运用IBM SPSS Statistics 25.0、IBM SPSS Modeler 18.0对中药进行频次分析、性味归经分析、高频药物关联规则分析等。结果:共纳入文献40篇,涉及中药组方40首,涉及单味中药95味,用药频次356次。高频药物(使用频次≥6)共17味,频次最高的药物为大黄。频次最高的药性、药味、归经分别为温性药、苦味药、脾经。关联规则分析提示:二阶关联规则支持度最高的组合为枳实+厚朴、大黄+厚朴,三阶关联规则支持度最高的组合为枳实+厚朴+大黄。结论:中药保留灌肠治疗MBO的用药以"泻下导滞、行气止痛"为基础治法,在临床治疗MBO取得了肯定的疗效。
Objective:To analyze the medication rules of treating MBO by TCM medicine retention enema,and to provide more references for clinical medication of MBO.Methods:In China national knowledge infrastructure database,Wanfang database and VIP Chinese journal platform,the relevant literature on treating MBO by TCM medicine retention enema January 2008 to May 2021 was retrieved.The TCM medicines used in the included literature were input into Excel 2019,and a database was established.The frequency analysis,property and flavor analysis,and high-frequency medicine association rule analysis of the included medicines were performed by IBM SPSS Statistics 25.0 and IBM SPSS Modeler 18.0.Results:A total of 40 studies were included,involving in 40 TCM prescriptions,95 TCM medicines,and 356 times of medication.There were 17 high-frequency medicines with a frequency of not less than 6 times,and Dahuang(Rhubarb)was the most frequently used medicine.The highest frequency of medicinal properties,medicinal taste and meridian tropism were warm medicines,bitter medicines and spleen meridian respectively.The association rules analysis showed that the highest supported medicines combinations in the second-order association rules were Zhishi-Houpo(Magnolia bark)and Dahuang-Houpo,and the highest supported medicines combination in the third-order association rules was Zhishi-Houpo-Dahuang.Conclusion:TCM medicine retention enema in treating MBO is based on the principle of reducing stagnation,and replenishing Qi(气)and blood to relieve pain,and it has achieved a definite effect in the clinical treatment of MBO.
出处
《中医临床研究》
2022年第1期52-55,共4页
Clinical Journal Of Chinese Medicine
关键词
恶性肠梗阻
恶性肿瘤
用药规律分析
保留灌肠
Malignant bowel obstruction
Malignant tumor
Medication rule analysis
Retention enema
