摘要
没药是经典的活血化瘀中药,具有活血定痛、消肿生肌之功效,临床应用广泛。从没药中分离得到的没药甾酮是其主要药效物质基础。没药甾酮为甾体类结构,在体内外有多种生理活性。包括《Science》等在内的期刊曾多次证实没药甾酮作为法尼醇X受体拮抗剂,有降血脂作用。近年来,诸多学者对没药甾酮的药理作用进行了广泛研究,发现其在抗炎、抗肿瘤、脑保护、降血脂、抗病毒等方面发挥重要作用。本文通过综述近年来没药甾酮的现代药理研究进展,以期为拓展没药的现代化应用和促进没药甾酮的新药研发提供新的思路。
Myrrh is one of classic traditional Chinese medicinal for promoting blood circulation and removing blood stasis.It has the effects of promoting blood circulation,relieving pain,reducing swelling and promoting muscle regeneration,and it has been widely used in clinic practice.Guggulsterone is identified as the main bioactive component of myrrh.Guggulsterone has many physiological activities in vivo and in vitro with a steroidal structure.Many professional journals,including Science,have confirmed that guggulsterone,as a farnesol X receptor antagonist,has a strong lipid-lowering effect.In recent years,many scholars have conducted extensive researches on the pharmacological effects of guggulsterone,and found that it played important roles in anti-inflammation,anti-tumor,cerebral protection,lipid-lowering,anti-virus and other aspects.This study reviewed the research progress in modern pharmacology of guggulsterone,in order to provide new ideas for expanding the modern application of myrrh and promoting the research and development of new drugs of guggulsterone.
作者
郭倩倩
柳敏娜
刘天龙
GUO Qianqian;LIU Minna;LIU Tianlong(The 944th Hospital of Joint Logistic Support Force of PLA, Jiuquan 735000, China;The 940th Hospital of Joint Logistic Support Force of PLA, Lanzhou 730050, China)
出处
《中医药学报》
CAS
2022年第4期115-118,F0003,共5页
Acta Chinese Medicine and Pharmacology
基金
国家自然科学基金项目(82003982)
甘肃省自然科学基金项目(20JR10R015)。
关键词
没药甾酮
药理作用
抗炎
抗肿瘤
脑保护
降血脂
Guggulsterone
Pharmacological action
Anti-inflammation
Anti-tumor
Cerebral protection
Lipid-lowering
