摘要
目的观察预防性应用聚乙二醇化重组人粒细胞刺激因子在妇科恶性肿瘤化疗中的临床效果。方法选取2018年12月—2019年12月山东大学齐鲁医院接收的妇科恶性肿瘤患者118例为研究对象,按照奇偶数随机分为观察组与对照组,每组59例。观察组患者在化疗的基础上预防性应用聚乙二醇化重组人粒细胞刺激因子,对照组患者单纯化疗。比较2组患者临床疗效、中性粒细胞降低发生率、恢复情况及不良反应。结果观察组患者总有效率为98.31%,高于对照组的84.75%(χ^(2)=6.993,P=0.008);观察组患者中性粒细胞降低发生率低于对照组(χ^(2)=7.230,P=0.007);观察组患者中性粒细胞恢复情况优于对照组(P<0.01);观察组患者不良反应总发生率低于对照组(χ^(2)=8.104,P=0.004)。结论预防性应用聚乙二醇化重组人粒细胞刺激因子具有显著效果,可加快妇科恶性肿瘤化疗患者恢复速度。
Objective To observe the clinical effect of preventive application of pegylated recombinant human granulocyte colony-stimulating factor in chemotherapy of gynecological malignant tumors.Methods 118 patients with gynecological malignancies accepted by Qilu Hospital of Shandong University from December 2018 to December 2019 were selected as the research objects,and the patients were divided into observation group and control group according to the odd-even random grouping method,59 cases in each group.The observation group received preventive use of pegylated recombinant human granulocyte colony-stimulating factor on the basis of chemotherapy,and control group received chemotherapy alone.The clinical efficacy,incidence of neutrophil reduction,recovery and adverse reactions were compared between the two groups.Results The total effective rate of patients in observation group was 98.31%,which was higher than 84.75% in control group(χ^(2)=6.993,P=0.008);The incidence of neutropenia in observation group was lower than that in control group(χ^(2)=7.230,P=0.007);The recovery of neutrophils in observation group was better than that in control group(P<0.01);The total incidence of adverse reactions in observation group was lower than that in control group(χ^(2)=8.104,P=0.004).Conclusion The preventive application of pegylated recombinant human granulocyte colony-stimulating factor has a significant effect,which can speed up the recovery of patients with gynecological malignant tumors from chemotherapy.
作者
刘洋
LIU Yang(Department of Drug Administration,Qilu Hospital of Shandong University,Shandong Province,Jinan 250000,China)
出处
《临床合理用药杂志》
2022年第7期31-33,37,共4页
Chinese Journal of Clinical Rational Drug Use
关键词
妇科恶性肿瘤
化疗
聚乙二醇化重组人粒细胞刺激因子
临床效果
Gynecological malignant tumors
Chemotherapy
Pegylated recombinant human granulocyte colonystimulating factor
Clinical effect
