摘要
目的探讨替罗非班在急性缺血性脑卒中机械取栓和静脉溶栓治疗中的安全性和有效性。方法选取2017年1月~2021年1月共收治的60例急性缺血性脑卒中患者作为研究对象,随机分为观察组与对照组,每组30例。对照组患者进行机械取栓治疗或静脉溶栓治疗,观察组在对照组基础上联合替罗非班治疗,对比两组患者的临床特征、治疗安全性与有效性。结果两组患者介入手术时间、术中血管痉挛、DSA示梗死血管以及溶栓治疗情况对比差异无统计学意义(P>0.05),观察组患者的二次取栓例数明显低于对照组(P<0.05);观察组患者治疗总有效率明显高于对照组(P<0.05);观察组患者有症状性脑出血、脑实质出血以及24 h后再闭塞等不良事件发生率明显低于对照组(P<0.05)。结论对急性缺血性脑卒中患者在机械取栓治疗基础上配合应用替罗非班治疗能够提升治疗效果,减少二次取栓,安全性好。
Objective To investigate the safety and efficacy of tirofiban in the treatment of mechanical thrombectomy for acute ischemic stroke.Methods 60 patients with acute ischemic stroke in our hospital from January 2017 to January 2021 were randomly divided into the observation group and the control group,30 cases in each group.The control group was treated with mechanical thrombectomy,and the observation group was treated with tirofiban on the basis of the control group.The clinical characteristics,treatment safety and effectiveness of the two groups were compared.Results There was no significant difference between the two groups in interventional operation time,vasospasm during operation,infarcted vessels shown by DSA and thrombolytic treatment(P>0.05),and the number of thrombectomy in the observation group was significantly lower than that in the control group(P<0.05);The total effective rate of the observation group was significantly higher than that of the control group(P<0.05);The incidence of symptomatic cerebral hemorrhage,cerebral parenchymal hemorrhage and reocclusion after 24 hours in the observation group was significantly lower than those in the control group(P<0.05).Conclusion On the basis of mechanical embolectomy,tirofiban can improve the therapeutic effect,reduce the number of embolectomy words,and has good safety.
作者
黄伟
马晓庆
龚考玲
HUANG Wei;MA Xiao-qing;GONG Kao-ling(Department of Neurology,Shimen County People's Hospital,Changde 415300,China)
出处
《中国处方药》
2022年第3期115-116,共2页
Journal of China Prescription Drug
关键词
替罗非班
急性缺血性脑卒
机械取栓
安全性
有效性
Tirofiban
Acute ischemic stroke
Mechanical bolt removal
Safety
Effectiveness
