摘要
汉防己甲素是一种双苄基异喹啉类生物碱,是粉防己中主要的生物碱,也是其质控成分之一。现代药理研究表明汉防己甲素在抗肿瘤、抗纤维化、肺部保护、心血管保护等方面具有显著作用,目前已有上市药物汉防己甲素片。近年来汉防己甲素及其衍生物的设计与合成受到国内外学者的广泛关注,通过对其化学结构进行修饰获得衍生物,以便提高其生物利用度和药理作用,本文综述了汉防己甲素的衍生物及其生物活性和作用机制的研究进展,旨在为今后对其进一步的研究与应用提供参考。
Tetrandrine, a kind of bisbenzylisoquinoline alkaloid, mainly exists in Stephania tetrandra as one of the quality control components.Modern pharmacological studies have indicated that tetrandrine exhibited anti-tumor, anti-fibrosis, pulmonary and cardiovascular protection activities, et al.In recent years, it is concerned by scholars that a series of tetrandrine derivatives were obtained to improve its bioavailability and pharmacological effects.This article reviews the research progress of tetrandrine derivatives along with their biological activities and mechanism of action in order to provide references for its further research and development.
作者
张翔宇
曹世杰
王小莹
丁丽琴
李巍
ZHANG Xiang-yu;CAO Shi-jie;WANG Xiao-ying;DING Li-qin;LI Wei(School of Chinese Materia Medica,Tianjin University of Traditional Chinese Medicine,Tianjin301617,China;Institute of Traditional Chinese Medicine,Tianjin University of Traditional Chinese Medicine,Tianjin301617,China;Faculty of Pharmaceutical Sciences,Toho University,Chiba274-8510,Japan)
出处
《中国药物化学杂志》
CAS
CSCD
2022年第1期43-52,共10页
Chinese Journal of Medicinal Chemistry
基金
国家重点研发计划项目(2018YFC1704500)。
关键词
汉防己甲素
衍生物
结构修饰
作用机制
药理作用
tetrandrine
derivative
structural modification
mechanism of action
pharmacological effect Research progress on tetrandrine and its derivatives
