摘要
自噬是一种进化保守的分解代谢过程,通过清除受损的细胞器和错误折叠的蛋白质,以维持细胞稳态。病原体感染触发的自噬可特异性地抑制机体内细菌的复制,从而保护细胞免受伤害。然而,许多病原微生物已进化出一系列对抗自噬的机制。本文综述聚焦胞内菌和宿主细胞之间的相互作用,简要概述胞内菌如何被自噬靶向清除,以及胞内菌如何调控自噬以促进其在细胞内的生存与繁殖。
Autophagy is an evolutionarily conserved self-balancing process that plays an important role in maintaining cell homeostasis by targeting damaged organelles and misfolded proteins to lysosomes for degradation.Autophagy triggered by pathogen infection can specifically inhibit the replication of bacteria in the host cell,thereby protecting cells from harm.In turn,many pathogenic microorganisms developed diverse strategies to avoid autophagy.In this review,we focus on the interaction between intracellular bacteria and host autophagy.We then dicusses how intracellular bacteria are targeted and eliminated by autophagy,and how intracellular bacteria manipulate autophagy to promote their intracellular colonization and growth.
作者
吴移谋
黄燕茹
卢思敏
王建业
WU Yimou;HUANG Yanru;LU Simin;WANG Jianye(Institute of Pathogenic Biology,Hengyang Medical School,University of South China,Hengyang,Hunan 421001,China)
出处
《中南医学科学杂志》
CAS
2022年第2期157-161,共5页
Medical Science Journal of Central South China
基金
国家自然科学基金(31872643)。
关键词
细胞自噬
胞内菌
自噬逃逸
autophagy
intracellular bacterial
autophagy escape
