摘要
近年来丙二酸二硫酯作为亲核活性增强的丙二酸酯类似物,在不对称有机小分子催化反应中得到了很好的应用,实现了一些普通丙二酸酯无法实现的反应。综述2007年至今,丙二酸二硫酯参与的有机小分子催化不对称反应及其在手性生物活性分子、手性药物合成中的应用研究进展。
Recently,dithiomalonates have been used as reactivity-enhanced malonate surrogates in many organocatalytic reactions,in which ordinary malonates cannot work.In this article,the research progress of organocatalytic reactions with dithiomalonates was reviewed as well as their applications in the synthesis of chiral bioactive molecules and chiral drugs from 2007 to 2020.
作者
杨鑫悦
李陆一
金辉
张立新
YANG Xin-yue;LILu-yi;JIN Hui;ZHANG Li-xin(Institute of Functional Molecules,Shenyang University of Chemical Technology,Liaoning Key Laboratory of Green Functional Molecular Design and Development,Shenyang Key Laboratory of Targeted Pesticides,Shenyang 110142,China;The 4th People's Hospital of Shenyang,Shenyang 110031,China)
出处
《当代化工》
CAS
2022年第2期436-440,共5页
Contemporary Chemical Industry
基金
辽宁省教育厅科学研究项目(项目编号:No.LQ2020025)。
