摘要
目的探讨钆塞酸二钠增强MRI肝胆期肝脏与脾脏信号强度(SI)比(LSC)、肝脏与门静脉SI比(LPC)及门静脉与脾脏SI比(PSC)评价肝硬化患者肝功能的临床价值。方法选取接受钆塞酸二钠增强MRI检查的128例患者,依据肝功能分为对照组(41例)、Child-Pugh A组(53例)、Child-Pugh B组(26例)和Child-Pugh C组(8例)。记录肝胆期肝脏、门静脉及脾脏SI,并计算LSC、LPC、PSC。采用单因素方差分析比较各组诸SI比值间的差异;采用Spearman线性相关分析比较SI比值与肝功能评分的相关性。结果LSC及LPC从对照组到Child-Pugh C组逐渐减低(P<0.001),PSC各组间差异无统计学意义。Child-Pugh评分与LSC及LPC呈中度负相关(r值分别为-0.514,-0.530,P均<0.001),MELD评分与LSC及LPC呈中度负相关(r值分别为-0.614,-0.620,P均<0.001)。结论钆塞酸二钠增强MRI肝胆期LSC及LPC能够反映肝硬化患者肝功能损害的严重程度,可以作为评价肝功能的影像学指标,PSC不能反映肝功能情况。
Objective To investigate the value of liver-to-spleen contrast ratio(LSC),liver-to-portal vein contrast ratio(LPC)and portal vein-to-spleen contrast ratio(PSC)at hepatobiliary phase on gadoxetic acid enhancement imaging for accessing the liver function.Methods Date of 128 patients with the normal(n=41),Child-Pugh class A(n=53),B(n=26)or C(n=8)who underwent Gd-EOB-DTPA-enhanced MRI were retrospectively reviewed.The signal intensity(SI)of the liver,spleen and portal vein at hepatobiliary phase(delayed 20 min)was recorded.LSC,LPC and PSC were calculated.One-way ANOVA was used to compare the differences between normal group and Child-Pugh class A,B,and C.Results LSC and LPC differed between control group and cirrhotic livers significantly(P<0.001).LSC and LPC constantly and significantly decreased from control group to cirrhotic livers with Child-Pugh class C at HBP imaging.There was no significant difference in PSC among the groups.There was a negative correlation between Child-Pugh score and LSC and LPC(r=-0.514 and-0.530,P<0.001),and negative correlation between MELD score and LSC and LPC(-0.614 and-0.620,P<0.001).Conclusion LSC and LPC on Gd-EOB-DTPA MR imaging can efficaciously indicate the severity of liver function in patients with cirrhosis,which might be used as alternatives imaging biomarker for assessing liver function.PSC cannot reflect the liver function of patients with cirrhosis.
作者
杨鸣
张月
程雯
王晗
郭盛仁
赵文露
顾清华
YANG Ming;ZHANG Yue;CHENG Wen;WANG Han;GUO Shengren;ZHAO Wenlu;GU Qinghua(Department of Radiology, The Second Affiliated Hospital of Soochow University, Suzhou 215004, China;Department of Radiology, Soochow Yongding Hospital, Suzhou 215200, China)
出处
《医学影像学杂志》
2022年第3期457-461,共5页
Journal of Medical Imaging
关键词
肝硬化
磁共振成像
钆塞酸二钠
肝功能
Liver cirrhosis
Magnetic resonance imaging
Gadoxetic acid
Liver function
