摘要
目的:探讨磁敏感加权成像(SWI)技术下脾脏铁沉积小体(GGBs)对门脉高压食管胃底静脉曲张(GOV)的预测价值。方法:109例肝硬化门静脉高压患者为观察组,110名体检健康志愿者为对照组;两组对象均行血液及核磁共振成像(MRI)检查,观察组患者另行内镜检查GOV情况;比较两组对象血液和MRI检查结果,分析影响GOV的因素及观察组GGBs检测结果与内镜确诊结果的相关性。结果:对照组MRI各序列下均未检出GGBs,观察组MRI四种序列下均检出GGBs共15例,不同序列下GGBs的检查率、平均检出数及检出总数比较,差异有统计学意义(P<0.05);其中SWI扫描下GGBs检出情况优于T1WI、T2WI和增强序列(P<0.05)。观察组SWI检出GGBs阳性48例,阴性61例。与对照组相比,GGBs阳性、GGBs阴性患者门静脉直径、脾脏指数(SI)值均增加(P<0.05),且GGBs阳性患者高于GGBs阴性患者(P<0.05)。GGBs阳性患者血小板数量、脾脏长径及血小板/脾脏长径比值低于对照组和GGBs阴性组(P<0.05),而GGBs阴性患者与对照组比较差异无统计学意义(P>0.05)。以内镜下诊断GOV作为金标准,观察组共诊断GOV 45例,且GGBs均为阳性,而45例患者常规MRI检查GGBs阳性为38例。不同严重程度GOV患者GGBs检出数差异有统计学意义(P<0.05)。相关性分析表明,GGBs检出数与GOV的严重程度呈正相关。结论:SWI可有效提高GGBs的检出率,GGBs阳性可反映出脾肿大状态,且GGBs检出数与GOV程度呈正相关,可能作为筛查GOV的有效无创检测指标。
Objective:To investigate the predictive value of Gamna-Gandy bodies(GGBS)on esophageal and gastric varices(GOV)in portal hypertension by magnetic sensitivity weighted imaging(SWI).Methods:109 cases of liver cirrhosis patients with portal hypertension were selected as the observation group and 110 cases of normal people as the control group.Blood and magnetic resonance imaging(MRI)were performed in both groups,patients in the observation group were examined for GOV by endoscopy.The blood and MRI results of the two groups were compared,and the factors affecting GOV and the correlation between the GGBS test results of the observation group and the endoscopic diagnosis results were analyzed.Results:There was no GGBs detected under all MRI sequences in the control group.In the observation group,there were 15 patients with GGBs detected under all four sequences.There was significant difference in the examination rate,average number and total number of GGBS under different sequences in observation group(P<0.05),among which GGBs detected under SWI scanning was significantly better than that of T1 W1,T2 W1 and enhanced sequence.With GGBs detected by SWI as the grouping standard for positive GGBs,48 cases of positive GGBs and 61 cases of negative GGBs in the 109 patients.Compared with the control group,the portal vein diameter and SI value of GGBs positive and GGBs negative patients had increased,and GGBs positive patients were higher than GGBs negative patients,the difference was statistically significant(P<0.05).The number of platelets,spleen length diameter and platelet/spleen length diameter ratio in GGBs positive patients were all lower than those in the control group and GGBs negative group,the differences were statistically significant differences(P<0.05),while GGBs negative and control group had no statistically significant differences(P>0.05).Endoscopic diagnosis of GOV as the gold standard,45 cases of GOV were diagnosed in the observation group,and GGBS were positive,while 38 cases were positive in routine MRI.Th
作者
李勇
李增晖
冀一帆
王俊
张小明
李兴辉
LI Yong;LI Zeng-hui;JI Yi-fan;WANG Jun;ZHANG Xiao-ming;LI Xing-hui(Sichuan Key Laboratory of Medical Imaging,Department of Radiology,Affiliated Hospital of North Sichuan Medical College;Department of Digestive Endoscopy,Affiliated Hospital of North Sichuan Medical College,Nanchong 637000,Sichuan,China)
出处
《川北医学院学报》
CAS
2022年第3期324-328,共5页
Journal of North Sichuan Medical College
基金
四川省南充市校合作科研专项(19SXHZ0287)
南充市校合作科研专项(19SXHZ0269)
川北医学院附属医院科研项目(2020ZD013)。
关键词
肝硬化
门静脉高压
食管胃底静脉曲张
内镜
磁敏感加权成像
Cirrhosis
Portal hypertension
Esophageal and gastric varices
Endoscopy
Magnetic sensitivity weighted imaging
