摘要
目的分析不同残余脂蛋白胆固醇(RLP-C)水平的2型糖尿病人群血脂亚组分指标特点,并探讨RLP-C水平异常与甘油三酯葡萄糖乘积(TyG指数)、超敏C反应蛋白(hs-CRP)等指标的关系。方法收集2019年9月至2020年9月上海德达医院全科医学科收治的203例2型糖尿病患者的病历资料,检测RLP-C,将60例RLP-C≥0.78 mmol/L患者纳入病例组,60例常规血脂检测结果正常且RLP-C<0.78 mmol/L患者纳入对照组。比较两组间年龄、体质量指数(BMI)、TyG指数、hs-CRP、总胆固醇(TC)、甘油三脂(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、空腹胰岛素(FINS)、空腹血糖(FBG)、糖化血红蛋白(HbA1c)、胰岛素抵抗指数(HOMA-IR)、性别、吸烟、饮酒、高血压史资料。采用Spearman相关分析RLP-C与TyG指数、hs-CRP的相关性。以RLP-C为因变量,年龄、性别、吸烟、高血压史、BMI、TyG指数、hs-CRP等指标作为自变量,进行单因素和多因素Logistic回归,分析RLP-C的影响因素。结果病例组BMI、TC、TG、LDL-C、FBG、FINS、HOMA-IR、HbA1c、TyG指数、hs-CRP水平均高于对照组,HDL-C水平低于对照组,差异有统计学意义(P<0.05)。2型糖尿病患者RLP-C与TyG指数、hs-CRP均呈显著正相关(r=0.75,P<0.05;r=0.32,P<0.05)。多因素Logistic回归分析结果显示,TyG指数升高是RLP-C升高的独立危险因素(OR=45.2,95%CI:9.7~209.6,P<0.05)。结论RLP-C与hs-CRP、TyG指数关系密切,TyG指数升高是导致RLP-C升高的独立危险因素。
Objective To analyze the characteristics of subcomponents of blood lipid in type 2 diabetic patients with different levels of residual lipoprotein cholesterol(RLP-C),to investigate the correlations between abnormal level of RLP-C and triacylglycerol glucose product(TyG index),hyper sensitive C-reactive protein(hs-CRP).Methods The medical records of 203 patients with type 2 diabetes from September 2019 to September 2020 in the Department of General Practice,Shanghai Delta Hospital were collected.RLP-C was detected,60 patients with RLP-C≥0.78 mmol/L were included in the case group,other 60 patients with normal routine lipids and RLP-C<0.78 mmol/L were included in the control group.Age,body mass index(BMI),TyG index,hs-CRP,total cholesterol(TC),triglyceride(TG),high density lipoprotein cholesterol(HDL-C),low density lipoprotein cholesterol(LDL-C),fasting insulin(FINS),fasting blood glucose(FBG),glycosylated hemoglobin(HbA1c),HOMA-IR,gender,smoking,drinking,hypertension history were compared between the two groups.Spearman correlation was used to analyze the correlations between RLP-C and TyG index,hs-CRP.With RLP-C as the dependent variable,age,gender,smoking,hypertension history,BMI,TyG index,hs-CRP and other indicators as independent variables,univariate and multivariate Logistic regression analysis were conducted to analyze the influencing factors of RLP-C.Results BMI,TC,TG,LDL-C,FBG,FINS,HOMA-IR,HbA1c,TyG index and hs-CRP levels in case group were higher than those in control group,HDL-C was lower than that in control group,the differences were statistically significant(P<0.05).There were significant positive correlations between RLP-C and TyG index,hs-CRP in type 2 diabetic patients(r=0.75,P<0.05;r=0.32,P<0.05).Multivariate Logistic regression analysis showed that increased TyG index was an independent risk factor for increased RLP-C(OR=45.2,95%CI:9.7—209.6,P<0.05).Conclusion RLP-C relates closely to hs-CRP and TyG index,the increase of TyG index was an independent risk factor for the increase of RLP-C.
作者
董国锋
苏珍珍
王占科
胡巍
李楠
袁建新
DONG Guofeng;SU Zhenzhen;WANG Zhanke;HU Wei;LI Nan;YUAN Jianxin(Ningbo Meikang Shengde Institute of Medical Laboratory,Ningbo,Zhejiang 315040,China;College of Laboratory,Hebei North University,Zhangjiakou,Hebei 075000,China;Department of General Practice,Shanghai Delta Hospital,Shanghai 201702,China;Department of Clinical Laboratory,Shanghai Delta Hospital,Shanghai 201702,China)
出处
《检验医学与临床》
CAS
2022年第7期938-942,共5页
Laboratory Medicine and Clinic
关键词
血脂亚组分
甘油三酯葡萄糖乘积
残余脂蛋白胆固醇
影响因素
lipid subcomponents
triacylglycerol glucose product
residual lipoprotein cholesterol
affecting factors
