摘要
目的探讨外周血循环肿瘤细胞(CTCs)检测在对慢性阻塞性肺疾病(COPD)患者进行肺癌筛查及预后判断中的作用。方法选择2015年6月至2017年9月该院收治的55例COPD合并肺癌患者纳入合并组,选择同期收治的60例单纯COPD患者纳入COPD组。所有患者均接受过外周血CTCs检测,比较两组患者、不同特征COPD合并肺癌患者CTCs阳性表达率,比较不同CTCs表达情况患者预后情况,比较各种检测方式对合并组患者肺癌确诊情况。结果COPD组患者的CTCs阳性表达率为0,合并组患者的CTCs阳性表达率为85.45%(47/55),差异有统计学意义(P<0.05)。支气管镜肺部活检、经皮穿刺肺活检、痰细胞检测、淋巴结活检对COPD合并肺癌患者的检出率均明显低于CTCs阳性表达率,差异有统计学意义(P<0.05)。肿瘤分期Ⅳ期及有远处转移COPD合并肺癌患者的CTCs阳性表达例数明显多于肿瘤分期Ⅲ期及无远处转移COPD合并肺癌患者,差异有统计学意义(P<0.05)。合并组中,CTCs阳性表达COPD合并肺癌患者平均生存周期为(7.36±1.85)个月,CTCs阴性表达COPD合并肺癌患者平均生存周期为(13.54±2.34)个月,整体阴性表达患者(COPD组60例与合并组中CTCs阴性表达患者8例)的平均生存周期为(20.76±4.24)个月,CTCs阳性COPD合并肺癌患者的平均生存周期明显短于CTCs阴性COPD合并肺癌患者、整体阴性表达患者,差异有统计学意义(P<0.05)。结论CTCs在COPD患者肺癌筛查中可作为重要参考指标,对患者病情评估和预后判断具有重要意义,CTCs阳性表达提示患者病情更严重,且预后较差。
Objective To explore the role of peripheral blood circulating tumor cells(CTCs)detection in lung cancer screening and prognosis judging of patients with chronic obstructive pulmonary disease(COPD).Methods A total of 55 patients with COPD complicated with lung cancer admitted to Tongchuan People's Hospital from June 2015 to September 2017 were included in the combined group,60 patients with simple COPD were included in the COPD group during the same period.All patients received peripheral blood CTCs detection.CTCs positive expression rates of patients in the two groups and patients with different characteristics of COPD complicated with lung cancer were compared,the prognosis of patients with different CTCs expression conditions were compared,and the diagnosis of lung cancer in patients with different detection methods were compared.Results The positive expression rate of CTCs was 0 in COPD group,which was 85.45%(47/55)in combined group,the difference was statistically significant(P<0.05).The detection rates of bronchoscopy lung biopsy,skin puncture lung biopsy,sputum cell detection and lymph node biopsy in COPD patients with lung cancer were significantly lower than the positive CTCs expression rate,with statistical significance(P<0.05).The positive expression rate of CTCs in patients with tumor stage Ⅳ and COPD complicated with lung cancer with distant metastasis were significantly higher than those in patients with tumor stage Ⅲ and COPD complicated with lung cancer without distant metastasis,the differences were statistically significant(P<0.05).In combined group,the mean survival period of CTCs positive COPD patients with lung cancer was(7.36±1.85)months,which of CTCs negative COPD patients with lung cancer was(13.54±2.34)months.The mean survival period of patients with overall negative expression(60 cases of COPD group and 8 cases of CTCs negative expression in combined group)was(20.76±4.24)months.The mean survival period of patients with CTCs positive COPD combined with lung cancer was significantly
作者
和建武
郭春丽
程西安
罗祥
HE Jianwu;GUO Chunli;CHENG Xi'an;LUO Xiang(Department of Respiratory Medicine,Tongchuan People's Hospital,Tongchuan,Shaanxi 727000,China)
出处
《检验医学与临床》
CAS
2022年第7期890-893,共4页
Laboratory Medicine and Clinic
基金
陕西省教育厅专项科研计划项目(16JK2031)。
关键词
循环肿瘤细胞
慢性阻塞性肺疾病
肺癌
circulating tumor cells
chronic obstructive pulmonary disease
lung cancer
