摘要
Few reports are available about prolonged shedding of coronavirus disease(COVID-19)virus,also known as severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),by immunocompetent patients.We report a case of an infected,immunocompetent person with 169 days of COVID-19 virus shedding during which time he had two brief periods when he tested negative for COVID-19 followed by again testing positive.We describe relevant clinical,immunological,and genomic features.We found that continuous and prolonged viral replication and infectivity existed in an immunocompetent COVID-19 patient,despite having high neutralizing antibody titers.
基金
The National Key Research and Development Program of China(2020YFA0707600)
the Scientific Research Project of Youan Hospital,CCMU,2020(BJYAYY-2020YC-01)
the National Key Research and Development Program of China(2020YFC0840800).
