摘要
目的分析不同胎龄不同日龄住院输血新生儿输血前肝功能检测指标,为深入研究不同胎龄新生儿肝功能指标参考范围提供数据支持。方法本研究采用多中心回顾性调研方式,以全国46家医院2017年1月1日~2018年6月30日收治的5669例输血新生儿为研究对象,按照统一的数据采集表,采集新生儿住院诊治数据,对采集数据按胎龄分为<32周组,32~36周组,≥37周组三组,分析不同日龄不同胎龄的新生儿输血前肝功能检测指标。结果(1)ALT结果显示,早产儿两组ALT中位数0~28 d分别为5~8 U/L和8~11 U/L,足月儿ALT较高为11~22 U/L,不同胎龄组内比较差异有统计学意义。相同日龄组间比较,ALT随胎龄增大逐渐增高,足月儿ALT值最高。各组间比较时除日龄13~14 d无差异外,其余日龄组间差异均有统计学意义。(2)不同胎龄新生儿随日龄增大,TBIL及DBIL呈先升高后减低趋势,相同日龄组间比较时,随胎龄增大TBIL及DBIL值更高。(3)三组TP值比较显示,出生后1~2 d下降,随后呈现逐渐上升趋势,不同日龄比较差异均有统计学意义,相同日龄组间比较时,随胎龄增大TP多呈现增高趋势。(4)相同日龄组间比较时,随胎龄增大ALB呈现增长趋势。结论肝功能指标参考区间与新生儿胎龄和日龄有关,研究不同胎龄不同日龄新生儿肝功能指标范围,有助于提高对新生儿疾病的精准治疗。
Objective To analyze the reference intervals of liver function index before blood transfusion in hospitalized newborns with different gestational ages and days-old,and complete the"reference value of liver function indexes"of hospitalized newborns.Methods This study adopted a multi-center retrospective survey method,taking 5669 newborns admitted to 46 hospitals in China from January 1,2017 to June 30,2018 as the research objects.According to a unified data collection table,the diagnosis and treatment data of hospitalized newborns were collected.The data were divided into three groups according to gestational age:<32 w group,32~36 w group,and≥37 w group,and the liver function indicators of different days-old and gestational ages were analyzed.Results(1)The results of ALT showed that the median ALT of 0~28 days in the two groups of preterm infants was 5~8 and 8~11 U/L,respectively.The higher ALT of term infants was 11~22 U/L,which was statistically significant among different gestational age groups.ALT increased gradually with gestational age among the same days-old groups,and the ALT value of full-term infants was the highest.There were significant differences among all groups except 13~14 days of age.(2)TBIL and DBIL of newborns with different gestational age increased at first and then decreased with the increase of days-old.TBIL and DBIL were higher with the increase of gestational age in the same days-old group.(3)TP value of the three groups decreased 1~2 days after birth and then showed a gradual upward trend,and there were statistical significance in comparison with different days-old.TP increased with the increase of gestational age in the days-old.(4)ALB increased with the increase of gestational age in the same days-old group.Conclusion The reference range of liver function index is related to neonatal gestational age and days-old.Studying the range of liver function index of neonates with different gestational age and days-old is helpful to improve the accurate treatment of neonatal diseases.
作者
马婷
苏舒
王李秦
宋奥微
孙杨
杨江存
MA Ting;SU Shu;WANG Li-qin(Department of Transfusion Medicine,Shaanxi Provincial People's Hospital,Xi'an 710068)
出处
《临床输血与检验》
CAS
2022年第2期163-169,共7页
Journal of Clinical Transfusion and Laboratory Medicine
基金
陕西省科技成果转移与推广计划-获奖成果转化项目(No.2020CGHJ-029)
陕西省人民医院领军人才项目(No.2021LJ-14)资助。
关键词
肝功能
新生儿
多中心研究
Liver function
Neonatology
Multicenter study
