摘要
腺苷酸活化蛋白激酶(adenosine activated protein kinase,AMPK)是一种能够感受细胞内能量变化的丝氨酸/苏氨酸蛋白激酶,在肿瘤的发生发展中起着十分重要的作用,根据AMPK催化亚基的差异分为AMPKα1和AMPKα2。AMPKα1亚基是AMPK的催化亚基,在不同组织器官中分布广泛。该文主要介绍AMPKα1的结构、激活方式和功能以及AMPKα1参与细胞内物质代谢的调节,总结归纳了AMPKα1在不同癌症中发挥的作用以及AMPKα1在不同癌症中作为药物靶点的潜在应用价值。AMPKα1可以作为癌诊断的标志物或药物靶点,为癌症的治疗提供一种思路,具有重要的临床意义。
Adenosine activated protein kinase(AMPK)is a serine/threonine protein kinase that can sense the change of intracellular energy.AMPK plays a critical part in the occurrence and development of tumors.According to the difference of AMPK catalytic subunits,it is divided into AMPKα1 and AMPKα2.The AMPKα1 subunit is the catalytic subunit of AMPK and is extensively distributed in the various tissues and organs.This review focuses on the structural,activated and functional aspects of AMPKα1 and the involvement of AMPKα1 in the regulation of intracellular substance metabolism,and summarizes the respective performances of AMPKα1 in different cancers and the corresponding potential applications of AMPKα1 as a drug target in the relevant cancers.AMPKα1 can be used as a diagnostic marker or drug target for cancer diagnosis and therapy,providing an idea for cancer treatment,which has importance clinical significance.
作者
黄小琴
贾玉芳
张海涛
HUANG Xiaoqin;JIA Yufang;ZHANG Haitao(Department of Biochemistry,Guangdong Medical University,Zhanjiang,Guangdong 524023,P.R.China)
出处
《华西医学》
CAS
2022年第3期460-467,共8页
West China Medical Journal
基金
国家自然科学基金(81772634)
佛山市第四人民医院“登峰计划”高水平医院建设开放课题(FSSYKF-2020019)。
