摘要
为揭示线粒体相关内质网膜(mitochondria associated membranes,MAMs)介导运动干预调控胰岛素抵抗的机制,综述MAMs的结构和功能、MAMs与胰岛素抵抗的联系,以及运动通过介导MAMs组分改善机体胰岛素抵抗的研究进展。结果表明,运动主要通过3条途径调控MAMs,改善胰岛素抵抗:1)Ca2+调控;2)对MAMs结构的修饰;3)调控MAMs处胰岛素信号相关分子。目前仍有4方面问题亟待解决:1)增加源于肝脏以外器官的证据支持;2)有针对性地检测不同细胞器/细胞结构中MAMs关联分子的表达;3)进一步探索MAMs结构与胰岛素抵抗的关系;4)揭示线粒体和内质网间距离与胰岛素抵抗的联系。
In order to reveal the mechanism of mitochondria associated membranes(MAMs)mediated regulation of insulin resistance by exercise intervention, the structure and functions of MAMs, association between MAMs and insulin resistance, as well as improvement of insulin resistance by exercise via MAMs were reviewed. The results showed that exercise regulated MAMs and insulin resistance through the following three ways: 1) Calcium regulation;2) modulation of the structure of MAMs;3) regulating insulin signaling related molecules located at MAMs. There are four research questions that need to be resolved: 1) Looking for evidence based on organs other than the liver;2) examining the expressions of MAMs associated molecules in different organelles/cellular structures;3) further exploring the association between MAMs structure and insulin resistance;4) investigating the association between mitochondria endoplasmic reticulum(ER) distance and insulin resistance.
作者
孙易
丁树哲
SUN Yi;DING Shuzhe(Key Laboratory of Adolescent Health Assessment and Exercise Intervention of Ministry of Educa‐tion,East China Normal Universi‐ty,Shanghai 200241,China;College of Physical Education and Health,East China Normal Uni‐versity,Shanghai 200241,China)
出处
《中国体育科技》
CSSCI
北大核心
2022年第3期76-81,共6页
China Sport Science and Technology
基金
国家自然科学基金项目(31600967)
中央高校基本科研业务费专项资金资助
青少年健康评价与运动干预教育部重点实验室建设项目(11000-30190-513300/006)。
