摘要
睡眠在能量平衡中起着很重要的作用,研究表明睡眠障碍是代谢性疾病发生的重要危险因素,控制能量代谢和睡眠之间的关系可以影响睡眠稳态及机体代谢率。中药在失眠防治中疗效显著,具有绿色、安全、副作用小的特征,受到国内外学者的广泛关注。近年来对于中药如何干预睡眠的机制研究取得了显著进展,该文综述了安神类中药化合物紫檀芪,单味中药酸枣仁,以及中药复方交泰丸、酸枣仁汤、天王补心丹、安寐丹、半夏厚朴汤、杞藿饮、松郁安神方、疏泄一号方等,调控能量代谢治疗睡眠障碍性疾病的研究进展,结果发现中药可以通过影响物质代谢、线粒体功能、氧化应激与炎症反应、食欲系统和生物钟系统等代谢相关途径干预睡眠剥夺模型,其中使用排名靠前的药物依次为酸枣仁、茯苓、五味子、丹参等,归心、肝经以调节血液运行,保障能量供应,发挥养心安神作用。笔者通过从能量代谢角度归纳中药治疗失眠等睡眠障碍性疾病的作用效果和机制,以期为今后疾病的进一步研究和探索提供参考。
Sleep plays an important role in energy balance.As reported,sleep disorder is an important risk factor for metabolic diseases.Controlling the relationship between energy metabolism and sleep can affect sleep homeostasis and body metabolic rate.Chinese medicine,with remarkable curative effects in the prevention and treatment of insomnia,has the characteristics of green,safety,and few side effects,and attracts extensive attention of scholars in the world.In recent years,remarkable progress has been made in the research on the mechanism of Chinese medicine in interfering with sleep.This paper reviewed the research progress of mindtranquilizing Chinese medicines,such as compounds(pterostilbene),Chinese medicinal drugs(Ziziphi Spinosae Semen),and Chinese medicinal prescriptions(Jiaotaiwan,Suanzaoren tang,Tianwang Buxindan,Anmeidan,Banxia Houpotang,Qihuo decoction,Songyu Anshen prescriptions,and Shuxie Yihao prescriptions)in the treatment of sleep disorders by regulating energy metabolism.The findings revealed that Chinese medicine can intervene in the sleep deprivation model by affecting metabolism-related pathways such as material metabolism,mitochondrial function,oxidative stress and inflammatory response,appetite system,and biological clock system.In terms of frequency of use,the top drugs are Ziziphi Spinosae Semen,Poria,Schisandrae Chinensis Fructus,and Salviae Miltiorrhizae Radix et Rhizoma which affect heart and liver meridians to regulate blood circulation,ensure energy supply,and play the role of nourishing the heart and tranquilizing the mind.The present paper summarized the effects and mechanisms of Chinese medicine in the treatment of insomnia and other sleep disorders from the perspective of energy metabolism to provide references for further research and exploration of diseases in the future.
作者
夏婧
徐波
谢光璟
黄攀攀
王平
XIA Jing;XU Bo;XIE Guang-jing;HUANG Pan-pan;WANG Ping(Institute of Geriatrics,Hubei University of Chinese Medicine,Wuhan 430065,China)
出处
《中国实验方剂学杂志》
CAS
CSCD
北大核心
2022年第7期40-48,共9页
Chinese Journal of Experimental Traditional Medical Formulae
基金
国家重点研发计划“中医药现代化研究”重点专项(2018YFC1705600)。
关键词
睡眠
能量代谢
分子机制
中药
安神
sleep
energy metabolism
molecular mechanism
Chinese medicine
mind tranquilizing
