摘要
目的探讨血液净化对急性苯系类稀料中毒的血清毒物浓度变化和预后影响的临床意义。方法收集武警特色医学中心急诊科2013年8月至2020年8月收治的急性苯系类稀料中毒患者44例,在行毒物检测明确稀料种类后分为血液净化组(24例)和常规治疗组(20例),分析两组患者一般资料、毒物浓度及预后,并对预后的影响因素进行logisitic回归分析,探讨血液净化的临床效果。结果血液净化组患者治疗后24 h的毒物浓度明显低于常规治疗组(t=6.76,P<0.001),毒物浓度降低程度明显高于常规治疗组患者(t=3.33,P=0.002)。血液净化组总体好转率为91.7%(22/24),高于常规治疗组(60.0%,12/20)。logisitic回归分析显示,血液净化治疗方法是影响患者预后的主要因素(OR=7.605×10^(-5),95%CI:6.604×10^(-8)~0.087,P=0.008),中毒剂量是影响患者预后的协同因素(OR=1.038,95%CI:1.008~1.068,P=0.011)。结论急性苯系类稀料中毒患者早期血液净化治疗能快速降低血液毒物浓度,避免病情进展,最终改善患者预后。
Objective To investigate the clinical significance of blood purification on changes in serum toxicant concentration and prognosis of acute benzene-based thinner poisoning.Methods A total of 44 patients with acute benzene-based thinner poisoning admitted to the emergency department of Characteristic Medical Center of Armed Police from August 2013 to August 2020 were collected and divided into a blood purification group(24 cases)and a conventional treatment group(20 cases),the general data,toxicant concentrations and prognosis of the two groups of patients were analyzed,and logistic regression analysis was performed on the influencing factors of the prognosis to explore the clinical effect of blood purification.Results The concentration of poisons in the blood purification group at 24 hours after treatment was significantly lower than that in the conventional treatment group(t=6.76,P<0.001),and the reduction in the concentration of poisons was significantly higher than that in the conventional treatment group(t=3.33,P=0.002).The overall improvement rate in the blood purification group was 91.7%(22/24),which was higher than that in the conventional treatment group(60.0%,12/20).Logisitic regression analysis showed that blood purification treatment method was the main factor affecting the prognosis of patients(OR=7.605×10^(-5),95%CI:6.604×10^(-8)-0.087,P=0.008),and the toxic dose was a synergistic effect on the prognosis of patients factor(OR=1.038,95%CI:1.008-1.068,P=0.011).Conclusion Early blood purification treatment in patients with acute benzene-based thinner poisoning can rapidly reduce blood toxin concentration,avoid disease progression,and ultimately improve patient prognosis.
作者
杨丽荣
陈献
温溁宇
哈玲梅
杨朝斌
Yang Lirong;Chen Xian;Wen Yingyu;Ha Lingmei;Yang Chaobin(Medical Department of Military General,The Characteristic Medical Center of Armed Police,Tianjin 300162,China;Department of Emergency,The Characteristic Medical Center of Armed Police,Tianjin 300162,China;Department of Nephrology,The Characteristic Medical Center of Armed Police,Tianjin 300162,China)
出处
《中华劳动卫生职业病杂志》
CAS
CSCD
北大核心
2022年第2期139-142,共4页
Chinese Journal of Industrial Hygiene and Occupational Diseases
关键词
中毒
稀料
苯
毒物分析
血液净化
Poisoning
Thinners
Benzene
Toxicological analysis
Blood purification
