摘要
目的 研究T2加权图像(T2WI)序列图像纹理分析(TA)在肝硬化背景下增生结节(DNs)及小肝癌(sHCC)鉴别诊断中的应用价值。方法 回顾性分析2016年1月至2020年11月收治的有完整术前常规MRI资料并经手术病理证实的单发肝硬化结节(直径≤3 cm)患者76例的临床资料,其中sHCC患者48例(设为sHCC组),DNs患者28例(设为DNs组)。两组均于手术病理学诊断前1周接受常规磁共振成像(MRI)检查,均行常规T2WI序列TA分析。选取结节最大层面轴位T2WI图像,利用Image J软件行病灶感兴趣区(ROI)手动勾画,提取灰度共生矩阵和直方图纹理参数,包括能量、熵、逆差距、相关性、对比度、平均值、峰度、偏度。对比两组灰度共生矩阵和直方图纹理参数变化情况,并采用受试者工作特性曲线(ROC)评价上述纹理参数对肝硬化背景下DNs与sHCC的鉴别诊断效能。结果 sHCC组能量、相关性分别为(15.50±7.25)×10^(-4)、(15.35±7.40)×10^(-4)显著低于DNs组(24.58±12.28)×10^(-4)、(33.72±14.71)×10^(-4)(P<0.05),熵(7.00±0.32)显著高于DNs组(6.62±0.63)(P<0.05),逆差距、对比度、平均值、峰度、偏度较DNs组无显著差异(P>0.05)。经ROC分析,能量、熵、相关性对肝硬化背景下DNs与sHCC均有一定鉴别诊断效能,曲线下面积分别为0.693、0.648、0.831。结论 常规T2WI序列TA下灰度共生矩阵和直方图纹理参数能量、熵、相关性鉴别诊断肝硬化背景下DNs与sHCC的效能较高,建议临床推广应用。
Objective To study on the application value of T2 weighted image(T2WI)sequence texture analysis(TA)in the differential diagnosis of proliferative nodules(DNs)and small hepatocellular carcinoma(sHCC)under the background of liver cirrhosis.Methods The clinical data of 76 patients admitted from January 2016 to November 2020 who had single cirrhotic nodule(diameter≤3 cm)confirmed by surgery and pathology were retrospectively analyzed.Within them 48 patients were diagnosed as sHCC(sHCC group)and 28 patients were diagnosed as DNs(DNs group).All patients received operation and obtained pathological diagnosis.Routine magnetic resonance imaging(MRI)examinations were performed in both groups of patients at 1 week before operation.Routine T2WI sequence-TA analysis was performed.The axial T2WI image of the largest section of the nodule was selected,and the region of interest(ROI)was manually outlined by Image J software.The gray level co-occurrence matrix and histogram texture parameters were extracted,including energy,entropy,inverse gap,correlation,contrast,average,kurtosis and skewness.The gray level co-occurrence matrix and histogram texture parameters of the two groups were compared,and the receiver operating characteristic curve(ROC)was used to evaluate the effectiveness of the above texture parameters for the differential diagnosis of DNs and sHCC under the background of liver cirrhosis.Results In SHCC group,the energy and the correlation were(15.50± 7.25)×10^(-4) and(15.35±7.40)×10^(-4),respectively,which was significantly lower than those of(24.58±12.28)×10^(-4) and(33.72±14.71)×10^(-4) in DNS group(P<0.05).The Entropy in SHCC group was(7.00±0.32),which was significantly higher than(6.62±0.63)in DNS group(P<0.05).The inverse difference,contrast,average,kurtosis and skewness of sHCC group had no significant difference compared with those of DNs group(P>0.05).ROC analysis showed that energy,entropy and correlation had a certain differential diagnosis efficacy on DNs and sHCC on the background of liver cirr
作者
冯权烨
耿承军
殷慧康
FENG Quan-ye;GENG Cheng-jun;YIN Hui-kang(Department of Medical Imaging,Wuxi Clinical College of Anhui Medical University,904 Hospital of Joint Logistics Force,Jiangsu 214044,China)
出处
《肝脏》
2022年第2期193-195,202,共4页
Chinese Hepatology
基金
无锡市科技发展计划项目(N20202036)。
关键词
磁共振成像
纹理分析
肝硬化
增生结节
小肝癌
Magnetic resonance imaging
Texture analysis
Liver cirrhosis
Proliferative nodules
Small hepatocellular carcinoma
