摘要
选择性宫内生长受限(sIUGR)是单绒毛膜性双胎严重并发症之一,增加围产期死亡率及发病率,并导致新生儿远期神经发育及认知能力受损,但其分子机制至今尚不明确。表观遗传学是指不改变DNA序列,通过某种方式使基因表达或细胞表现型出现可遗传的变化,最新研究发现sIUGR胎盘组织中存在DNA甲基化、非编码RNA调控及组蛋白修饰等表观遗传学调控方式的改变,证明表观遗传学调控机制参与了sIUGR的发病机制。因此,探索与sIUGR相关的表观遗传学调控机制对了解sIUGR的发病原因及确定临床诊疗策略可以提供新的思路。
Selective intrauterine growth restriction(sIUGR)is one of the serious complications of monochorionic twins,which increases perinatal mortality and morbidity,and causes long-term neurodevelopment and cognitive impairment of newborns,but its molecular mechanism is still unclear.Epigenetics refers to the fact that gene expression or cell phenotypes can be heritable in some way without changing the DNA sequence.The latest researches have found that there are DNA methylation,non-coding RNA regulation,and histone modification in placental tissue of the fetuses with sIUGR.The change in the way of epigenetic regulation proves that the epigenetic regulation mechanism affects the growth and development of the placenta,and it participates in the pathogenesis of sIUGR.Therefore,exploring the epigenetic regulation mechanism related to sIUGR can provide new ideas for understanding the pathogenesis of sIUGR and determining clinical diagnosis and treatment strategies.
作者
李春晓
贺光
王彦林
LI Chunxiao;HE Guang;WANG Yanlin(International Peace Maternity and Child Health Hospital Affiliated to School of Medicine, Shanghai Jiaotong University, Shanghai, 200030)
出处
《中国计划生育学杂志》
2022年第1期241-244,共4页
Chinese Journal of Family Planning
基金
国家自然科学基金(81971401)。
